The Safety And Efficacy Of Nebulized Application Of Lidocaine In Postoperative Analgesia After Oral Soft Tissue Surgery

Objective: To investigate the safety and efficacy of nebulized application of lidocaine in postoperative analgesia after oral soft tissue surgery,and to provide information for improving postoperative analgesia methods in oral soft tissue surgery.Methods: A total of 40 patients,aged 18-60 years,with ASA grade Ι-Ⅱ,were performed for oral soft tissue surgery from August 2018 to August 2019.Forty patients requiring oral soft tissue surgery were randomly assigned to receive nebulized application of 2%lidocaine or 0.9% saline with 20 cases in each group.All patients were anesthetized with fentanyl 1.5ug /kg,propofol 2.5mg /kg,cisatracurium 0.15 mg /kg.The same experienced anesthesiologist intubated the endotracheal tube.Anesthesia was maintained with 1-2MAC sevoflurane inhalation combined with 0.1-0.3ug /kg/min remifentanil hydrochloride and 1 ug/kg/min atracurium homeopathic.The visual analogue scale(VAS)pain score,the vital signs,the dosages of sufentanil and side effects were recorded.Results: There were no statistically significant differences in gender,age and body weight between the two groups.There were no statistically significant differences in surgical types between the two groups.There was no significant differences in VAS pain score between the two groups before nebulized application of lidocaine.The VAS pain score in the nebulized lidocaine group were significantly lower than those in the control group 0.5h,2h and 4h after nebulized application of lidocaine.Heart rate,systolic pressure and diastolic pressure did not differ between the two groups.Patients in the nebulized lidocaine group required lower doses of sufentanil than those in the control group(9.00±8.52 vs.45.00±13.18 μg,p<0.001).Conclusion: Nebulized application of lidocaine was found to be safe and effective.It was associated with reduced sufentanil dosages.