Effects Of Blood-activating And Blood-breaking Medicines On JAK2/STAT3 Pathway Expressions In Aortic Arteries Of ApoE Gene Dificient Mice Atherosclerosis Models

Objective To Objective investigate the difference of blood activating traditional Chinese medicine(Angelica sinensis,Ligusticum Chuanxiong)and blood breaking traditional Chinese medicine(Sanleng,Rhizoma zedoariae)on JAK2/STAT3 in aorta of mice with atherosclerosis.Methods Seventy ApoE gene defect models mice mice were fed high fat diet for 12 weeks to prepare atherosclerosis model.After the success of the model preparation,they were randomly divided into model group,statin group,low activity group,low burst group,high activity group and high burst group,continuous lavage 8 weeks,model group,bottling volume such other groups distilled water.Another 10 C57BL/6J mice as blank group were given equal volume of distilled water.IL-β content in serum and protein content of JAK2,STAT3 and SOCS3 in aorta of mice were detected.Results(1)Compared with blank group,serum IL-1β in model group was significantly increased(P<0.01);Compared with the model group,the contents of IL-1β in serum were decreased in each drug groups.The atorvastatin group was better than the high blood breaking group(P<0.05),the high blood breaking group was better than the high blood group(P<0.01),and the high dose group was better than the low dose group(P<0.01).The effect of the low blood breaking group and the low blood group was similar(P>0.05).(2)Compared with blank group,the protein contents of JAK2 and STAT3 in aorta of model group were significantly increased and the protein content of SOCS3 was significantly decreased(P<0.01).Compared with model group,drug groups can promote the mice aorta SOCS3 protein expression in the inhibition of JAK2 and STAT3 protein expression(P<0.01 or P<0.05),the atorvastatin group is superior to invigorate the circulation of the blood breaking group and blood group(P<0.01 or P<0.05),the blood breaking group is better than that of blood group(P<0.01 or P<0.05),high dose group is better than that of low dose group(P<0.01).Conclusion Activating blood medicine and Breaking blood medicine can inhibit atherosclerosis by promoting the expression of SOCS3 protein expression inhibition pathway JAK2/STAT3 in mouse aorta.