| Objective: The purpose of this study was to discuss the correlation between the changes of serum cystatin C and β 2-microglobulin levels in patients with non-ST segment elevation acute coronary syndrome(non-ST-segmentelevationacutecoronarysyndrome,NSTE-ACS)and the global(GRACE)risk score of acute coronary event registration,so as to provide theoretical basis for early clinical prevention and control of non-ST segment elevation acute coronary syndrome.Methods: A total of 90 patients who were diagnosed with NSTE-ACS in the sixth Department of Cardiology of the second Hospital of Hebei Medical University from January 2020 to December 2020 were selected.According to the GRACE risk score,the GRACE risk score ≤ 108 was defined as the low risk group(n = 15),the middle risk group(n = 45)and the high risk group(n =30).Another 44 patients with coronary artery stenosis less than 50% in the same period were selected as the control group.The general clinical data,cystatin C and β 2-microglobulin of each group were compared,and the correlation between cystatin C and β 2-microglobulin and Grace risk score was analyzed.Results:1.Compared with the control group,AST level in NSTE-ACS group increased significantly,and the difference was statistically significant.However,there was no significant difference in age,heart rate,systolic blood pressure,BMI,TG,TC,ALT,Cr,history of hypertension and diabetes between NSTE-ACS group and negative control group.2.Compared with the control group,the levels of cystatin C and β2microglobulin in NSTE-ACS group were significantly higher(P < 0.05).The level of cystatin C in NSTE-ACS groups with different GRACE scores was compared,and the level of cystatin C was high-risk > medium-risk> low-risk,with statistical significance(P < 0.05).Comparing the levels ofβ2-microglobulin among different GRACE score groups,the levels of β2-microglobulin in high-risk group were significantly higher than those in middle-risk group and low-risk group(P<0.05),but there was no significant difference between middle-risk group and low-risk group(P>0.05).3.Correlation analysis between serum cystatin C and β2-microglobulin and GRACE score in NSTE-ACS patients showed that cystatin C andβ2-microglobulin were positively correlated with GRACE score,pearson correlation coefficients were 0.547 and 0.626,respectively,with statistical significance(P<0.05).4.Multiple linear regression analysis showed that GRACE score was positively correlated with age,heart rate,creatinine,cystatin C andβ2-microglobulin of NSTE-ACS patients(r = 0.710,0.231,0.215,0.597,0.6-26,P<0.01).Cystatin C,age and β2 microglobulin have linear regression relationship with GRACE score.5.ROC curve was drawn: with GRACE score greater than 140 as the boundary,the area under the curve corresponding to cystatin c was 0.699(95% CI: 0.580-0.817,P < 0.05),and the best boundary point was 0.945mg/L;The area under the curve corresponding to β2-microglobulin is 0.761(95% CI: 0.654-0.868,P < 0.05),and the best boundary point is 1.73 mg/L.Conclusions:1.Cystatin C and β2-microglobulin are the risk factors of NSTE-ACS.2.The level of cystatin C was positively correlated with GRACE risk score,and there were significant differences among low risk group,medium risk group and high risk group in GRACE score,which suggested that cystatin C might be related to the risk degree and prognosis of NSTE-ACS.3.The level of β2-microglobulin was positively correlated with GRACE risk score,and the level of β2-microglobulin in high-risk group was significantly higher than that in middle-risk group and low-risk group,and the difference was statistically significant,suggesting that β 2-microglobulin may be related to the risk degree and prognosis of NSTE-ACS.4.Age,cystatin C and β2-microglobulin can be used as independent predictors of NSTE-ACS risk stratification. |
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