Meta Analysis Of The Treatment Of Chronic Hepatitis B With YGJ Decoction Or Combined With Other Drugs

Objective:To systematically evaluate the clinical efficacy of modified Y GJ decoction or combined with other drugs in the treatment of chronic hepatitis B in recent years,and to further guide the clinical drug use.Methods:Search from CNKI,VIP,Wanfang,Cocrhane Library,Pubmed,EMBase and other databases about all the clinical randomized controlled trials(RCT)of YGJ decoction or combined with other drugs in the treatment of chronic hepatitis B since the establishment of the database until October 2020 by computer.According to inclusion and excluding criteria to screen literature and the final literature are evaluated with the quality evaluation of the risk assessment tool of Cochrane,and at last extract data to analysis by RevMan5.4 software.RESULTS:A total of twelve studies were included in this meta-analysis.A total of 971 participants were included.①YGJ decoction or combined with other drugs had advantages in clinical efficacy,and the difference was statistically significant(RR=1.24,(1.07,1.44,P<0.05).②YGJ decoction or combined with other drugs had advantages in reducing ALT,AST,TBIL levels and increasing the rate of ALT normalization(P<0.05)[MDALT水平=-7.75,(-10.63,-4.86);RRALT复常率=1.48,(1.17,1.87);MDAST水平=-7.72,(-11.9 8,-3.47);MDTBIL水平=-3.46,(-6.30,-0.61)];③There was no significant difference in HBV-DNA negative conversion rate and HBeAg negative conversion rate(P>0.05)[RR HBeAg 阴转率=0.88,(0.12,6.41);RR HBV-DNA 阴转率=1.27,(0.76,2.12)].④YGJ decoction or combined with other drugs had advantages in reducing the levels of PCⅢ,HA,LN and Ⅳ-C(P<0.05)[MDPCⅢ水平=-59.16,95%CI(-89.58,-28.73);MDHA水平=-62.72,95%CI(-74.02,-51.42);MDLN水平=-40.38,95%CI(-69.41,-11.36);MDⅣ-c水平=-31.03,95%CI(-43.23,-18.82)].Conclusion:1.YGJ decoction and combination with other drugs in the treatment of chronic hepatitis B is better than the control group in clinical efficacy.2.YGJ decoction and combination with other drugs in the treatment of chronic hepatitis B in improving liver function is better than the control group.3.YGJ decoction and combination with other drugs in the treatment of chronic hepatitis B is superior to the control group in terms of anti-liver fibrosis.