Serum Non-enzymatic Antioxidant And Thyroid Hormone Levels In Adolescents Depressive Patients With Non-suicidal Self-injury

Objective: The purpose of this study was to investigate the relationship between serum levels of non-enzymatic antioxidants and thyroid hormones with the risk of non-suicidal self-injury in adolescents with depression.Methods: A total of 383 adolescent patients with depression aged 13 to20 years were included.We divided them into two groups(NSSI and non-NSSI group)according to whether whether accompanied by NSSI behavior.The levels of non-enzymatic antioxidants(serum albumin,total bilirubin and uric acid)and thyroid hormones(free triiodothyronine,free thyroxine and thyrotropin)were determined,and the differences between the two groups were compared.Results: A decrease in albumin,total bilirubin,uric acid and free triiodothyronine levels was observed in patients with non-suicidal self-injury than those without non-suicidal self-injury.Correlation analysis revealed that free triiodothyronine and free thyroxine were positively correlated with albumin.Furthermore,thyroid stimulating hormone was found to have a significant negative correlation with total bilirubin,with free triiodothyronine having a significant positive correlation with uric acid.Conclusions: These findings suggest that variations in antioxidant and thyroid hormones levels can be related to non-suicidal self-injury in depressed adolescents.