Effects Of Different Treatment For Patients With Acute Cerebral Infarction With M2 Segment Of Middle Cerebral Artery Occlusion

Objective:To observe and compare the clinical efficacy of conventional treatment,intravenous thrombolysis and endovascular therapy of acute ischemic stroke with M2 segment of middle cerebral artery(MCA-M2)occlusions,providing evidence for optimizing treatment options.Methods: Totally 76 acute MCA-M2 occlusion patients respectively received conventional therapy(conventional therapy group,n=31),intravenous thrombolysis therapy(intravenous thrombolysis group,n=27)and endovascular therapy(endovascular therapy group,n=18).The relevant clinical efficacy indicators of 3 groups were compared.Results: Compared with conventional therapy group,the proportion of falling national institutes of health stroke scale(NIHSS)≥4 points at 24 hours post treatment in endovascular therapy group(22.58% vs 83.33%)was significantly higher than in conventional therapy group(both unadjusted and adjusted P < 0.01).The follow-up 90-day good outcome rates(58.06% vs 81.48% vs 83.33%),the incidence of asymptomatic intracranial hemorrhage(3.23% vs 22.22% vs 22.22%)in intravenous thrombolysis group and endovascular therapy group both were higher,and the follow-up 90-day mortality rates(3.23% vs 22.22% vs 22.22%)were lower(unadjusted P<0.05)than conventional therapy group,while after adjustment for age,baseline NIHSS score and time from onset to admission,no statistical differences were found(all P > 0.05).In intravenous thrombolysis group,1 case occurred symptomatic intracranial hemorrhage.And in endovascular therapy group,the vascular recanalization rate was94.44%.Conclusion: For the patients with MCA-M2 occlusive acute cerebral infarction,emergency endovascular therapy could rapidly improve neurological deficit early.