| Objection: The aim of this meta-analysis is to evaluate clinical effects of Lactobacillus strains in the prevention of AAD in children from the aspects of probiotic species,the daily dosage of probiotics and the definitions of AAD.Design: Pub Med:Cochrane Library,MEDLINE,EMBASE databases were searched.For the meta-analysis,the pooled relative risk(RR)and95% confidence intervals(CI)were estimated to reveal the association between Lactobacillus strains and antibiotic-associated diarrhoeaResults: A total of eight randomized controlled trials(RCTs)involving1453participants met the inclusion criteria.Compared with placebo,the species of Lactobacillus rhamnosus only is effective in the prevention of AAD among children with antibiotic administration The reduction was observed in groups where the daily dosage of probiotics was 10^10CFU(colony forming units)and 10^9 CFU.The reduction was also revealed in groups where AAD is defined as more than 3 times of loose or watery stools for 48 hours.And the mean duration of diarrhoea is shorter in probiotic groups(3.65 days)than placebo groups(4.20 days).The incidence of Clostridium difficile infection and adverse effects were not statistically significant between the two groups.Conclusion: Compared with placebo,the use of Lactobacillus rhamnosus,one species of Lactobacillus strains,is beneficial to children with antibiotics administrations in the prevention of AAD when the daily dosage of probiotics is no less than 10^9 CFU and AAD is defined as more than 3 times of loose or watery stools for 48 hours.And there are no differences in adverse effects between two groups. |
