Influence Of Infusion Rate Of Human Serum Albumin On The Outcome Of Neonatal Capillary Leak Syndrome

Objective: To investigate the effect of different infusion rates of human serum albumin on the outcome of neonatal capillary leak syndrome.Methods: The children with neonatal capillary leak syndrome admitted to the Department of Neonatology,Chongqing Medical University from October 2017 to October 2020 were retrospectively analyzed.The general data at admission,clinical conditions before and after albumin infusion during hospitalization,and hospital stays were collected.The survival outcomes of the children were followed up for 28 days.The patients were divided into routine infusion group and rapid infusion group according to albumin infusion rate.The clinical data and clinical outcomes of the two groups were compared and analyzed.Results: 1.A total of 64 children with neonatal capillary leak syndrome were included.There was no significant difference in the basic data between the two groups,which were comparable.2.After human serum albumin infusion,systolic blood pressure and diastolic blood pressure increased,24-hour urine volume per kilogram of body weight and ALB level increased,CLI and creatinine decreased significantly,but body weight also increased.3.After rapid infusion of albumin,the systolic blood pressure,24-hour urine volume per kilogram of body weight and the increase level of urine volume were significantly increased compared with the routine infusion group,and the degree of weight gain was decreased compared with the routine infusion group;secondly,the ALB level was effectively increased and the CLI level was effectively decreased in the rapid infusion group;in addition,the incidence of renal injury was not increased in the rapid infusion group compared with the routine group,and there was no significant difference in post-infusion creatinine level,the length of hospital stay and duration of mechanical ventilation between the two groups.4.There was no significant difference in the 28-day survival rate between the two groups.Conclusion: 1.The use of human serum albumin can improve the clinical condition of children with neonatal capillary leak syndrome,and rapid infusion of human serum albumin may be more effective for the treatment of neonatal capillary leak syndrome.2.Different infusion rates of human albumin may not significantly improve the clinical outcomes of children.