| Objective:To observe the clinical efficacy of Chinese medicine leaching combined with calcipotriol betamethasone gel in the treatment of mild and moderate scalp psoriasis and the treatment of this program on the levels of T cell subsets(CD4+,CD8+,CD4+/CD8+)in the peripheral blood of patients The impact of the index,to explore its mechanism of action,for the clinical treatment of mild to moderate scalp psoriasis to provide a safe and efficient combined treatment of Chinese and Western medicine.Methods:According to the diagnostic criteria of Chinese and Western medicine formulated in this topic,60 patients with mild and moderate scalp psoriasis were selected,and they were divided into the experimental group and the control group with 30 cases each according to the principle of randomized control grouping.The experimental group was treated with traditional Chinese medicine leaching combined with calcipotriol betamethasone gel;the control group was treated with calcipotriol betamethasone gel combined with calcipotriol liniment.The treatment cycle of the two groups of patients was 2 months.Record and count the skin lesions,symptom scores,Scalpdex scores,total cost,and T cell subsets(CD4+,CD8+,CD4+/CD8+)in the peripheral blood of the two groups of patients before treatment,2 weeks of treatment,4 weeks of treatment,and 8 weeks of treatment.)Level index and adverse reactions that occurred during the treatment process.Through statistical analysis and processing of relevant data,the clinical efficacy of traditional Chinese medicine leaching combined with calcipotriol betamethasone gel in the sequential treatment of mild and moderate scalp psoriasis was confirmed.After the course of treatment,all patients except those who were judged to be invalid for clinical efficacy were followed up for 3 months to analyze and compare the recurrence of the two experimental groups.Results:1.There was no significant difference in age,gender,course of disease,PASI score,Scalpdex score,peripheral blood T cell subsets CD4+,CD8+ content,and CD4+/CD8+ value between the two groups of patients before treatment(P>0.05),indicating that it can be performed Compare.2.The PASI scores of the two groups were compared with those before treatment in the second,fourth,and eighth weeks.P<0.05,which was statistically significant,indicating that the two schemes can significantly improve the symptoms of scalp lesions in patients.PASI score in the test group: P<0.05 compared with the 4th week and the 2nd week;P<0.05 compared with the 8th week and the 4th week.PASI score in the control group: P<0.05 when comparing the 4th week with the 2nd week;comparing the 8th week with the 4th week,P>0.05.PASI scores between the two groups: compared at the 2nd week,P<0.05;compared at the 4th week,P>0.05;compared at the 8th week,P>0.05.It shows that the control group plan takes effect more quickly in the first 2 weeks of treatment,and its effect is mainly concentrated in the first 4 weeks.The skin lesion symptoms of patients in the 4th to 8th week are not significantly improved compared with the previous 4 weeks;while the experimental group The effect of the program is relatively stable,and the patient’s skin lesion symptoms can be continuously improved throughout the treatment cycle.3.Comparing the Scalpdex scores between the two groups before and after the experiment,P<0.05,which is statistically significant,indicating that the two treatment options can significantly improve the quality of life of patients.The comparison of scores between the two groups in the second and fourth weeks,P>0.05,was not statistically significant;the comparison of scores between the two groups in the eighth week,P<0.05,the difference was statistically significant,indicating that the difference was statistically significant in the fourth to eighth The improvement in the quality of life of patients in the weekly trial group was higher.4.Comparing the CD4+,CD8+,CD4+/CD8+ values in the peripheral blood of the two groups before and after the experiment,P<0.05,which is statistically significant,indicating that the two schemes can make the patient’s peripheral blood CD4+,CD8+,CD4+/CD8+ levels improve.The CD4+,CD8+,CD4+/CD8+ values in the peripheral blood were compared between the two groups at the 4th weekend,P>0.05,which was not statistically significant;the CD4+,CD8+,CD4+/CD8+ values in the peripheral blood between the two groups at the 8th weekend were similar In comparison,P<0.05,which is statistically significant,indicating that the experimental group’s program improved the patients’ peripheral blood CD4+,CD8+,CD4+/CD8+ levels better than the control group in the 4th to 8th week.5.Throughout the course of treatment,the total average cost of the experimental two groups was compared,P=0.026<0.05,which was statistically significant,indicating that the experimental group’s selected treatment plan was more economical than the control group.6.Comparing the total hormone usage of the experimental two groups,P<0.05,the difference was statistically significant,indicating that the experimental group’s selected treatment plan was significantly less hormone usage.7.After the treatment period,the total effective rates of the two experimental groups were 96.55% and 93.33%,respectively.After the rank sum test,the difference was not statistically significant(P>0.05),indicating that the total clinical efficacy of the two regimens was equivalent.8.During the treatment period,the incidence of adverse reactions in the experimental group was 3.44%,and the incidence of adverse reactions in the control group was 23.33%.According to statistical calculations,the difference between the two was statistically significant(P<0.05),indicating that the treatment regimen in the experimental group is more safe high.9.After the course of treatment,all patients except those who were judged to be invalid for clinical efficacy were followed up for a period of 3 months,and the relevant data were recorded and processed.The recurrence rates of the two experimental groups were 3.57% and 25.0%respectively.According to statistical calculations,the difference between the two was significant.(P<0.05),indicating that the treatment plan of the experimental group has better durability.in conclusion:1.Chinese medicine leaching combined with calcipotriol betamethasone gel sequential treatment program is applied to the treatment of mild to moderate scalp psoriasis.Compared with the clinically commonly used treatment programs in Western medicine,the efficacy is not inferior to that of the other party and can also be greatly improved.It reduces costs,reduces the use of hormones,improves patient compliance,and has better safety and longer-lasting efficacy,which is worthy of promotion.2.The mechanism of action of traditional Chinese medicine leaching combined with calcipotriol betamethasone gel sequential therapy may be related to the reformation of the body’s immune function by regulating the levels of T lymphocyte subsets(CD4+,CD8+,CD4+/CD8+)in the patient’s peripheral blood.So as to achieve the treatment of diseases. |
