The Correlation Between Different Syndrome Typesand Risk Factors Of Bone Metastasis In Patients With Non-small Cell Lung

Objective: To analyze the risk factors of bone metastasis in 61 patients with NSCLC by retrospective clinical study,construct a prediction model of bone metastasis of NSCLC,explore the correlation between different syndrome types and these risk factors,and explore the relationship between high risk clinical factors and TCM syndrome types of NSCLC,so as to provide a reliable reference for the early prevention and treatment of bone metastasis in TCM.Method:(1)61 patients with NSCLC were analyzed retrospectively.The clinical data were collected,including age,sex,smoking history,tumor pathological type,hemoglobin,serum albumin,serum sodium ion,lactate dehydrogenase,carcinoembryon antigen,alkaline phosphatase level,lymph node metastasis,physical status score(ECo G score)at the initial diagnosis,and the time of treatment with Chinese medicine and Chinese patent medicine were collected to establish relevant factors of bone metastasis Table: the data are analyzed statistically by spss26.0software to form conclusions and discuss.Based on the above independent risk factors,a prediction model is established to distinguish the risk groups and calculate the risk probability of bone metastasis in different populations.(2)Kaplan Meier test was used to analyze the effect of traditional Chinese medicine on the bone metastasis progression time of NSCLC patients.(3)Chi square test was used to analyze the correlation between different TCM Syndrome Types and independent risk factors.Result:1.61 patients with NSCLC showed that poor physical state(ECo G score≥ 2),serum alkaline phosphatase increased,and pathological type was adenocarcinoma,which was independent risk factors for bone metastasis in non-small cell lung cancer(P < 0.05);the prediction model established based on the above risk factors was estimated to be the risk of bone metastasis in low,medium and high risk groups within one year 34.6%,67.1%and 100% were of predictive significance(P < 0.001).2.K-M curve showed that the treatment group of traditional Chinese medicine had statistical significance for prolonging the progress of bone metastasis(P < 0.05).3.There was no statistical significance between the difference of physical fitness(ECo G score ≥ 2)between non-small cell lung cancer patients with different TCM syndromes and the previously obtained risk factors(P = 0.53 > 0.05),indicating that there was no correlation between them;there was correlation with the pathological classification of adenocarcinoma(P < 0.05),and the distribution of syndrome types was:21 cases(45.6%)of lung qi deficiency syndrome > 9 cases(19.6%)of Qi Yin deficiency syndrome(19.6%))=The syndrome types were: 14 cases(56%)> phlegm turbid stasis syndrome 5 cases(20%);Qi Yin deficiency syndrome 4 cases(16%);Blood Stasis Syndrome 2 cases(8%).Conclusion:1.Poor physical condition(ECo G score ≥ 2),serum alkaline phosphatase rise,and pathological classification of lung cancer adenocarcinoma are independent risk factors for bone metastasis in non-small cell lung cancer patients.2.The clinical treatment of non-small cell lung cancer patients with traditional Chinese medicine can prolong the progress time of bone metastasis.3.The pathological classification is adenocarcinoma,serum alkaline phosphatase is the most common in non-small cell lung cancer patients with lung qi deficiency syndrome.For the future patients with lung qi deficiency syndrome,we should be vigilant,monitor as early as possible to prevent bone metastasis.