The Value Of P504s,34βE12,Ki-67 And PSA In Diagnosis And Prognosis Of Prostate Cancer

Objective:In recent years,the incidence of prostate cancer has been increasing.Advanced prostate cancer has a poor prognosis,high cost,and a negative impact on patients’ quality of life.Therefore,how to improve the diagnosis rate and prognosis of early prostate cancer is the focus of clinical research.This paper aims to study the value of P504 S,34βE12,Ki-67 and PSA in the diagnosis and prognosis of prostate cancer.Methods:24 cases in the study group were selected from PCa confirmed by pathology in the urology department of our Hospital from October 2018 to August 2020,and 33 cases of Benign Prostate Hyperplasia(BPH)confirmed by pathology in the same period were selected as the control group.The expression of PSA,P504 s,34βE12 and Ki-67 in prostate tissues was detected by Chemiluminescence immunoassay and immunohistochemical methods.Results:1.The positive expression rates of P504 s,34βE12 and TPSA or F/TPSA in PCa patients were 95.8%,12.5% and 87.5%,respectively.The positive rates in BPH patients were 9.1%,93.9% and 27.3%,The difference between the two groups was statistically significant(P<0.05).2.PCa bone or lymph node metastasis was positively correlated with Ki-67(r=0.423,P<0.05)and Gleason score(r=0.446,P<0.05),indicating a stronger correlation with Gleason score.Conclusion:1.The combined detection of P504 s,34βE12 and PSA is helpful for the diagnosis and differential diagnosisof PCa.2.A high Gleason score or high expression of Ki-67 may indicate a high risk of PCA metastasis and poor prognosis.3.Gleason score may be more associated with PCA bone or lymph node metastasis than Ki-67.