Clinical Research On Retention Enema With Qing Chang Hua Zuo Liquid Treatment For Patients With Large Intestine Damp-heat Type Ulcerative Colitis

Objective: Ulcerative colitis(UC) is a inflammatory bowel disease(IBD), belongs to a chronic nonspecific colonic inflammatory disease. At present the disease cause and pathogenesis has not yet fully understood. Because of difficult diagnosis, the lesion range, long course, cure is difficult and the illness is often easy to relapse again.Severe cases can even threaten life. As the lack of special treatment, UC has become a medical related research hot spot. In recent years, its incidence was significantly higher than before. So further explore its pathogenesis and therapy of traditional Chinese medicine(TCM) will make a very vital significance to improve the cure rate, shorten the course, reduce the complications and lower recurrence rate. This research chooses patients with Large intestine damp-heat type Ulcerative Colitis, on the basis of the relevant theories of traditional Chinese medicine, in which called damp-heat can leads to pathogenic characteristics of ulcerative colitis. Combining the theory of "Zhuo Du" profound understanding of the disease and the role of relative viscera we can use methods which called “qingrejiedu”, “huayuzhitong”, “shengjilianchuang” to heal the disease.we can observe and evaluate clinical curative effects of retention Enema with Qing Chang Hua Zhuo liquid treatment for Patients with Large intestine damp-heat type Ulcerative Colitis.Discussing the feasibility, efficacy and advantages of this treatment is for providing the basis of its clinical application.Methods: All the 60 cases were chosen from hospitalized patients and outpatient department of He Bei Provincial Hospital of traditional Chinese medicine who with diagnosis of large intestine damp-heat type UC, male 32 cases, female 28 cases, adopting the rule of random, were divided into three groups: 20 in the A group, 20 in the B group and another in the C group. A is treatment group,B and C are the control groups.After statistics analysis, three groups of cases material in gender, age, course, illness state, colonoscopy mucosal lesions, there were no significant difference(p>0. 05) be comparable. In the treatment group A, 100 ml compound qingchanghuazhuo liquid were given via retention enema every night before sleeping, while the patients also need take Mesalazin Enteric-coated Tablets 1.0g every time,4 times a day. In the group B the patients were given via retention enema with 100 ml xileisan solution, gentamycin, dexamethasone, such as mixed liquid instead of compound qingchanghuazhuo liquid. And as the A group patients also need take Mesalazin Enteric-coated Tablets 1.0g every time, 4 times a day.In the group C the patients were just given Mesalazin Enteric-coated Tablets 1.0g every time,4 times a day.The group A and the group B were both retention enema combining with oral administration.The group C just given oral administration.All the patients were treated for 4 weeks.After treatment, used statistical methods to compare three sets of clinical symptoms and signs, colonoscopy mucosal lesions curative effect, the comprehensive effect and Chinese Medicine comprehensive syndromes curative effect, etc.Results: After treatment, the three groups of patients with clinical comprehensive curative effect were comparable. The group A’s total effectiveness 95%, the group B’s total effectiveness75%, the group C’s total effectiveness 60%. After statistics analysis, P<0.05,statistical significance was found among total clinical comprehensive curative effect, the group A was better than the group B and group C; After treatment, the three groups of patients with UC score were comparable, the group A 4.23 士 2.15, the group B 8.26 土 1.98, the group C10.37 士 2.03. After statistics analysis, P<0.05, significant difference, the group A was better than the group B and group C in UC curative effect; After treatment, all kinds of the clinical symptoms in the three groups were comparable, after statistics analysis, P<0. 05, the group A was better than the group B and group C in clinical symptoms curative effect; After treatment, the three groups of patients with colonoscopy mucosa lesions curative effect were comparable, after statistics analysis, P<0. 05, the group A was better than the group B and group C in colonoscopy mucosal lesions curative effect.Conclusion: The study used the Traditional Chinese Medicine(TCM) compound Qing Chang Hua Zhuo Liquid retention enema to treat large intestine damp-heat type ulcerative colitis, basing on Chinese medicine syndrome differentiation and treatment principle, and gave full play to the advantages of Traditional Chinese Medicine’s individual therapy. Through the retention enema this way, made solution direct to lesions, adequately protected, promoted to repair mucous membrane, cured ulcerative colitis. It is an effective and convenient with slight side-effects for controlling ulcerative colitis(UC). So it is worthy of further study and clinical application extensively.