Meta-analysis Of Risk Factors For Blood Transfusion Reactions In Hospitalized Patients

Objective:At present,the reports of blood transfusion reactions in domestic and foreign literature are limited to a certain region or a certain hospital,and the results of various studies cannot be unified.Through systematic reviews,there are currently more discussions on the risk factors of blood transfusion reactions in hospitalized patients.Provide evidence-based medicine clinically and formulate corresponding prevention and treatment measures.Methods:Computer search of Pubmed,The Cochrane Library,Ovid,Web of Science,CNKI,Wan Fang Data,VIP,CBM and other databases to collect case-control studies and cohort studies on risk factors related to adverse reactions in hospitalized patients after blood transfusion.The search time is 2015 January of year to February of 2021.Two researchers independently screened the literature,extracted data according to the same inclusion and exclusion criteria,and evaluated the risk of bias.The results were systematically evaluated using Rev Man5.3 software.Results:35 studies were included,including 9,694,788 subjects,involving 13 risk factors.Meta analysis results show:(1)General factors: female [OR=1.25,95%CI(1.06,1.47),P=0.007],age ≤18 years old [OR=3.40,95%CI(1.89,6.11),P<0.0001 ] The incidence of adverse blood transfusion reactions in hospitalized patients is higher;(2)Past history factors: primary blood disease [OR=0.12,95%CI(0.06,0.17),P<0.001],history of blood transfusion [OR=5.05,95%CI(3.84,6.65),P<0.00001],allergic history[OR=5.65,95%CI(2.44,13.09),P<0.001] hospitalized patients with higher incidence of adverse blood transfusion reactions;(3)Blood Factors related to product type: red blood cell transfusion [OR=0.71,95%CI(0.52,0.96),P=0.03],platelet transfusion[OR=2.19,95%CI(1.44,3.32),P=0.0002 ] The incidence of adverse blood transfusion reactions in hospitalized patients is higher;(4)Other factors: the interval between blood issuance to transfusion ≥30min [OR=2.52,95%CI(1.54,4.19),P=0.0004],the number of blood transfusions ≥3 [OR=6.85,95%CI(4.96,9.47),P<0.00001] hospitalized patients had a higher incidence of adverse blood transfusion reactions.Conclusion:The hospitalized blood transfusion patients are female,age ≤18 years old,previous primary blood disease,previous blood transfusion history,previous history of allergies,transfusion of red blood cell blood products,transfusion of platelets,time between blood to transfusion ≥30min,number of transfusions ≥3 All of them are related risk factors for adverse blood transfusion reactions.Due to the limitations of included studies,the above conclusions still need to be further confirmed by largescale and high-quality studies.