The Effect Of Preemptive Analgesia On Postoperative Immune Function In Patients With Colorectal Carcinoma

Objective:To study the effect of preemptive analgesia on postoperative immune function of patients undergoing radical surgery for colorectal carcinoma.Methods:A total of 100 patients who underwent laparoscopic colorectal carcinoma surgery in the Department of Gastrointestinal Surgery of the Second Affiliated Hospital of Guilin Medical University from October 2018 to December 2020 were randomly divided into control group(placebo group)(n=46)and experimental group(advanced analgesia group)(n=54).The levels of immune indicators such as CD4~+,CD8~+,CD4~+/CD8~+,NK cells,Ig A,Ig G,and Ig M levels of the two groups of patients were detected and analyzed 1day before surgery,2 hours after surgery,and 1,3,and 5 days after surgery.Results:There were no significant differences in the immune indicators of the two groups before surgery:serum CD4~+,CD8~+,CD4~+/CD8~+,NK cells,and serum Ig A,Ig G,Ig M levels(P>0.05).The levels of CD4~+,CD8~+,CD4~+/CD8~+,NK cells,Ig A,Ig G,and Ig M in the two groups after surgery were significantly lower than those before surgery(P<0.05);the experimental group was 2 hours after surgery and at1,3and 5 days after surgery.The levels of CD4~+,CD8~+,CD4~+/CD8~+,Ig A,and Ig G were significantly higher than those of the control group(P<0.05);the serum NK cells and Ig M levels of the experimental group on the 5th day after surgery were not significantly different from those of the control group(P>0.05).Conclusion:The perioperative application of preemptive analgesia for colorectal carcinoma patients has a significant effect on postoperative pain relief,can reduce the suppression of postoperative immune function,and play a positive role in the rapid recovery of patients after surgery.