| Background :As a common surgical disease in clinical practice,Acute Pancreatitis(AP)is characterized by rapid onset,severe illness,rapid course and high fatality rate.Pathogenesis of acute pancreatitis complicated,course faster,according to most of the research results,acute pancreatitis is mainly caused by inflammatory cytokines,show the chain effect of cascading waterfalls,acute pancreatitis inflammation worse,lead to systemic inflammatory response syndrome(SIRS)and multiple organ dysfunction(MODS)and multiple organ failure(MOF),and even lead to death occurs.Nowadays,medical technology is constantly updated and improved.Compared with the previous medical level,the medical community now has a better understanding of the pathological mechanism of acute pancreatitis and shows more advantages in terms of treatment measures.However,it cannot prevent the rising mortality rate.Ulinastatin is a highly effective protease inhibitor extracted from human urine.It can inhibit myocardial inhibitory factors to a certain extent,and it can also prevent the release of inflammatory factors in tissues by eliminating oxygen free radicals.The results show that in the case of acute pancreatitis,ulinastatin will play a certain therapeutic effect,reducing the level of inflammatory factors in patients and improving the immunity of patients.The clinical therapeutic effect of ulinastatin has been recognized by most scholars,but there are still some controversies in medicine.objective :This study will focus on exploring the use of octreotide alone and octreotide combined with ulinastatin in the treatment of acute treatment based on the same convent ional treatments as fasting water,gastrointestinal decompression,anti-infection,antispas modic analgesia,acid suppression,and fluid resuscitation.Comparison and analysis of clinical effects of pancreatitis.Methods: Two groups of patients were given the same conventional treatments as fasting water,gastrointestinal decompression,anti-infection,antispasmodic and analgesic,acid suppression,and fluid resuscitation.The control group was given 0.3 mg of octreotide mixed with 250 ml of normal saline and pumped in for 12 hours;On the basis of the control group,the group was given 100,000 U of Ulinastatin plus 500 ml of5% glucose intravenously,1 time/d,and the dose was reduced to 50,000 U after 3 days.Both groups were treated continuously for 7-14 d.Results: After treatment,the blood amylase of the control group and the test group were(104.06±131.99)and(199.43±227.89)respectively;the white blood cell values were(6.18±2.37)and(6.36±2.43)respectively;the C-reactive protein was(7.33±15.04),(4.12±2.93);blood glucose were(5.64±1.05),(6.56±2.77);blood calcium were(2.17± 0.12),(2.15 ± 0.13),except for blood calcium,the differences were statistically significant Meaning(P <0.05).Conclusion:The key to the treatment of acute pancreatitis is to inhibit the activity of trypsin and keep the internal environment relatively stable.Conventional treatments such as fluid resuscitation and anti-infection cannot effectively inhibit and repair the further damage of trypsin.Octreotide is a common therapeutic drug in clinical practice.The main effect of this therapeutic drug is to prevent pancreatic secretion,reduce the burden of the stomach and intestine,and inhibit growth.In addition,octreotide also has certain repair function for pancreatic cells.Although octreotide has been shown to be effective in the treatment of acute pancreatitis,the therapeutic effect is not particularly significant.Ulinastatin,as an acidic glycoprotein,has certain advantages in inhibiting trypsin activity,and can also inhibit systemic inflammation,so as to protect the organ function of patients.Combined treatment of acute pancreatitis with ulinastatin and octreotide can effectively reduce the inflammatory response,make the therapeutic effect more significant,but also have a certain relief effect on clinical symptoms,improve the prognosis of patients,and have a more efficient clinical effect. |
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