Selection Of Surgical Timing For Traumatic Cataract With And Ruptured Anterior Capsular

Objective:1 、 By measuring the changes of the levels of inflammatory cytokine interleukin-6(IL-6)and transforming growth factor-β2(TGF-β2)in the aqueous fluid of patients with traumatic cataract at different stages,the relationship between them and traumatic cataract with ruptured anterior capsule was understood.2 、 By comparing the postoperative visual acuity and the incidence of complications of patients with different surgical timing,the choice of surgical timing for traumatic cataract with ruptured anterior capsule was discussed,so as to provide reference for clinical treatment.Methods:Prospective study,collect the Affiliated Eye Hospital of Nanchang University in October 2018 to January 2020 in accordance with the standard set of former capsule rupture of corneal perforation of 45 patients with traumatic cataract cases(45 eyes),as the observation group,were randomly divided into 3 groups: group A,15 cases,within 3 days after injury of cataract ultrasonic emulsification gettering plus iol implantation;In group B,15 patients underwent phacoemulsification and intraocular lens implantation 4 ～ 7 days after injury.In group C,15 patients underwent phacoemulsification and intraocular lens implantation 1 week after injury.The patients were followed up for half a year,and the incidence of postoperative best corrected visual acuity and complications(uveitis,secondary cataract,secondary glaucoma,etc.)were recorded.Fifteen patients(15 eyes)with age-related cataract were selected as control group(D group).The levels of IL-6 and TGF-β2 in the aqueous humor of 4groups were detected by ELISA.The corresponding statistical methods were used to compare and analyze the four groups of data.Results:After 6 months of follow-up,there was no significant difference in visual acuity improvement among the observation group(F=2.217,P=0.439).The incidence of complication uveitis in group A was higher than that in group C(P=0.042),and there was no significant difference between the other groups.IL-6 content in observation group 3 was higher than that in control group(P < 0.05),but there was no statistical significance among observation groups 3(P > 0.05).Comparison of TGF-β2 content between B and C groups and the control group showed statistically significant difference(P < 0.05),while there was no statistically significant difference between other groups(P > 0.05).Conclusion:1、The levels of IL-6 and TGF-β2 in aqueous humor of traumatic cataract patients with ruptured anterior capsule were significantly higher than those of age-related cataract patients,and the levels of IL-6 and TGF-β2 in aqueous humor of patients were correlated with the degree of intraocular inflammatory reaction.2、There was no significant difference in the best corrected visual acuity of traumatic cataract with ruptured anterior capsule by different surgical timing.The postoperative complications were lower and the surgical outcome was better when the surgery was performed after 1 week under the control of inflammation.