| Objective: To study the relationship between the level of serum heat shock protein70(HSP70)and the prognosis of patients with hepatocellular carcinoma treated by transcatheter arterial chemoembolization(TACE).Method: From September 2018-September 2019,the patients with advanced primary liver cancer who received TACE therapy in our hospital were selected as the liver cancer group,and the healthy volunteers who received physical examination at the same time were selected as the control group.The serum HSP70 level of the patients in the liver cancer group before operation and at 1d,7d and 14 d after operation and the serum HSP70 level of control group were detected.The recurrence of the patients after TACE was followed up and the progression free survival was calculated.Log-Rank test was used to analyze the difference of progression free survival,Cox regression model was used to analyze the influencing factors of progression free survival,ROC curve was used to analyze the correlation between HSP70 and recurrence.Result: The level of serum HSP70 in patients with liver cancer was significantly higher than that in the control group(P<0.05),and there was no difference of serum HSP70 levels before and 1 day after operation between patients without progression and recurrence(P>0.05),and the serum HSP70 levels of patients with recurrence at 7 and 14 days after operation were higher than those of patients without progression(P<0.05);compared with patients with low level of HSP70 at 7 and 14 days after operation,the serum HSP70 level in patients with high level of HSP70 was shortened.The maximum diameter of tumor,vascular invasion and HSP70 level at 7 days after operation were the influencing factors of progression free survival(P<0.05).The Serum HSP70 level at 7d postoperatively was correlated with postoperative recurrence.Conclusion: The increase of serum HSP70 level at 7d after TACE in patients with advanced HCC was associated with and correlated with postoperative recurrence. |
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