| Objective:On the basis of lifestyle guidance,Jian-Pi-An-Shen-Fang was applied to treat patients with obstructive sleep apnea-hypopnea syndrome（OSAHS）complicated with anxiety of phlegm dampness internal resistance type.The changes of clinical symptoms and related indicators before and after treatment were analyzed to evaluate the clinical efficacy and safety of Jian-Pi-An-Shen-Fang,so as to provide new ideas for clinical treatment of traditional Chinese medicine.Method:From February 2020 to December 2020,72 patients with mild to moderate OSAHS complicated with anxiety in the respiratory department of Fuzhou hospital of traditional Chinese medicine were selected.According to the random number table,they were divided into the experimental group and the control group according to the order of treatment,with 36cases in each group;The changes of AHI,LSa O2,ESS score,TCM syndrome score and HAMA score before and after treatment were studied.Result:1、PSG efficacy evaluation:in the experimental group,0 case was cured,7 cases were markedly effective,18 cases were effective,and 11 cases were ineffective,with a total effective rate of 69.4%;in the control group,0 case was cured,2 cases were markedly effective,9 cases were effective,and 25 cases were ineffective,with a total effective rate of30.6%.The difference between the two groups was statistically significant（P=0.001,P<0.05）。2、TCM syndrome efficacy evaluation:in the experimental group,0 cases were cured,1case was markedly effective,28 cases were effective,7 cases were ineffective,the total effective rate was 80.1%;in the control group,0 cases were cured,0 cases were markedly effective,12 cases were effective,24 cases were ineffective,the total effective rate was 33.3%,the difference between the two groups was statistically significant（P=0.000,P<0.05）。3、HAMA efficacy evaluation:in the experimental group,0 cases were cured,2 cases were markedly effective,26 cases were effective,8 cases were ineffective,the total effective rate was 77.8%;in the control group,0 cases were cured,0 cases were markedly effective,15cases were effective,21 cases were ineffective,the total effective rate was 41.7%,the difference between the two groups was statistically significant（P=0.001,P<0.05）。4、Comparison of AHI,LSa O2,ESS score and HAMA score:There was no significant difference in AHI,LSa O2,ESS score and HAMA score between the two groups before treatment（P>0.05）.The AHI,LSa O2,ESS and HAMA scores of the experimental group before and after treatment were statistically significant（P<0.05）;the AHI,LSa O2and ESS scores of the control group before and after treatment were not statistically significant（P>0.05）;the HAMA scores of the control group before and after treatment were statistically significant（P<0.05）;the AHI,LSa O2,ESS and HAMA scores of the two groups after treatment were statistically significant（P<0.05）.5、Comparison of TCM syndrome integral:There was no significant difference in the total score of TCM syndrome and single TCM syndrome between the two groups before treatment（P>0.05）,which was comparable.There were statistically significant differences in the total scores of TCM syndromes between the two groups before and after treatment（P<0.05）.The experimental group was significantly higher than the control group in the improvement of single symptom scores and total scores of snoring,apnea and suffocation,irritability and anxiety,palpitation,drowsiness,heavy weight,insomnia and forgetfulness（P<0.05）.There was no significant difference in the scores of snoring,apnea and suffocation,irritability and anxiety,palpitation,insomnia and forgetfulness in the control group before and after treatment（P>0.05）,but there were significant differences in the scores of drowsiness and heavy body（P<0.05）。6、During the treatment of this study,no abnormality was found in the safety indexes of the two groups.Conclusion:1、Lifestyle guidance can reduce sleep breathing events,increase sleep continuity,improve hypoxia,reduce drowsiness and heavy body symptoms to some extent,but it has no obvious effect on daytime symptoms.Jian-Pi-An-Shen-Fang can reduce AHI and improve LSa O2level,so as to reduce the night hypoxia,reduce the number of wakefulness,optimize sleep,alleviate daytime fatigue and sleep,and improve the quality of life.2、Both lifestyle guidance and Jian-Pi-An-Shen-Fang can significantly reduce HAMA score of OSAHS patients,but the combined use of Jian-Pi-An-Shen-Fang has a higher reduction rate.Jian-Pi-An-Shen-Fang can be used to treat the heart and spleen,tonify the spleen,remove phlegm,nourish the heart and blood,promote liver depression,calm the mind,nourish the heart and liver soul,stabilize the emotion and relieve the anxiety.Therefore,the improvement of anxiety is better than the simple lifestyle intervention.3、Jian-Pi-An-Shen-Fang is safe and effective in the treatment of phlegm-dampness syndrome type of patients with OSAHS and anxiety. |
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