Analysis On Early Prediction Of Progressive Ischemic Stroke With Galectin-3 And NLR

Objective: To explore the relationship between plasma galectin-3(Gal-3),neutrophil to lymphocyte ratio(NLR)and progressive ischemic stroke(PIS)and their early predictive value for PIS.Methods: 105 patients with acute ischemic stroke(AIS)who were hospitalized in the Department of Neurology,Minda Hospital Affiliated to Hubei University for Nationalities were collected as AIS group,while58 healthy subjects from the Health Examination Center of the same Hospital were collected as control group during December 1,2019 to December 31,2020.General data,clinical data and laboratory data were collected.Nevous blood samples were collected from each person to detect plasma Gal-3 levels.Single factor analysis and binary Logistic regression were used to analyze the influence of each index on the incidence of AIS.If an AIS patient has an increase of 4 points or more on the National Institute of Health Stroke Scale,it’s considered as a PIS patient.Based on this,the AIS group was divided into PIS group and non-PIS group.Binary Logistic regression was used to analyze the influence of plasma Gal-3 and NLR on the incidence of PIS.Receiver operating characteristic(ROC)cerve was used to analyze the early predictive value for PIS with plasma Gal-3 and NLR.Results :(1)Between the AIS group and the control group,through binary Logistic regression analysis,high-level plasma Gal-3,high NLR,high-level homocysteine,high-level D-dimer,high admission systolic pressure,and high-level apolipoprotein A1 are Influencing factors of AIS(OR=0.582,P=0.001;OR=0.609,P=0.030;OR=0.877,P=0.01;OR=0.419,P=0.008;OR=0.941,P=0.002;OR=37.839,P=0.016).(2)Between the PIS group and the non-PIS group,through binary Logistic regression analysis,plasma high-level Gal-3(P=0.044)and high NLR(P=0.040)are the influencing factors of PIS.(3)ROC curve shows: Area under the curve(AUC)of plasma Gal-3 is 0.676,the best diagnostic cut-off value is 13.83 ng/m L,with sensitivity of 62.2% and specificity of 76.7%;AUC of NLR is 0.677,best diagnostic cut-off value is 3.61,with sensitivity of 66.7% and specificity of 71.7%;the combined AUC of the two indexes is 0.709,the best diagnostic cut-off value is17.15,with sensitivity of 93.3%,and specificity of 41.7%.Conclusion:(1)Plasma plasma high-level Gal-3,high NLR,high-level homocysteine,high-level D-dimer and high systolic pressure are independent risk factors of AIS,high-level apolipoprotein A1 is an independent protective factor of AIS.(2)Plasma high-level Gal-3 and high NLR are independent risk factors for PIS in AIS patients.(3)Plasma Gal-3 or NLR have diagnostic value for predicting the occurrence of PIS,the diagnostic accuracy of plasma Gal-3 combined with NLR in predicting the occurrence of PIS is higher than that of plasma Gal-3 Or NLR.High plasma level of Gal-3 combined with NLR has certain value for early identification of patients with PIS.