Effect Analysis Of Percutaneous Vertebral Augmentation In The Treatment Of Patients With Multiple Myeloma Vertebral Body Lesions

Objective: The aim of this study was to retrospectively analyze the curative effect of percutaneous vertebral augmentation(PVA)in the treatment of multiple myeloma vertebral body lesions during the past three years in the Zhongda Hospital Affiliated to Southeast University.This provides a theoretical basis for promoting the application of vertebral augmentation in the vertebral lesions of multiple myeloma patients.Methods: Clinical data of 31 MM patients with vertebral body lesions from January 2016 to December 2018 in the Department of Hematology,Zhongda Hospital Affiliated to Southeast University,including vertebral injury location,vertebral injury symptoms,visual analog scale(VAS)and physical scores(Karnofsky,KPS),and the type of surgical procedure,were collected and then retrospectively analyzed.SPSS 20.0 software was used for analysis.The measurement data was described with mean and standard deviation,and the counting data was expressed as rate.VAS and KPS scores 1 day before and 1 month after PVA and 1 year after PVA were compared by paired t test.VAS and KPS scores of percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP)were compared by independent sample t test 1day before surgery and 1 month after surgery respectively.Results: Up to January 2020,the pain and quality of life after percutaneous vertebral augmentation were significantly improved in 31 MM patients with vertebral body lesions in the Department of Hematology,Zhongda Hospital Affiliated to Southeast University.The VAS score of the patients was 7.90±1.01 points before surgery,and decreased to 2.65±1.14 points at 1 month after surgery,and 1.52±0.93 points at 1 year after surgery.Paired t test was performed on VAS score at 1 day before surgery,1 month after surgery and 1 year after surgery respectively,and there were statistically significant differences(All P< 0.001).The KPS score was 33.23±10.45 points before surgery,and decreased to 55.16±9.61 points at 1month after surgery,and 64.19±10.25 points at 1 year after surgery.Paired t test was performed on KPS score at 1 day before surgery,1 month after surgery and 1 year after surgery respectively,and there were statistically significant differences(All P<0.001).Independent sample t test was performed on VAS scores of PVP group and PKP group at 1 day before surgery and 1 month after surgery,respectively,and there was no statistically significant difference between them(P>0.05).Conclusion: Vertebral augmentation surgery is an effective method for the treatment of pain caused by vertebral lesions and can significantly improve the quality of life in patients with MM.The type of surgical procedure,including PVP and PKP,has no obvious effect on the treatment of MM patients with vertebral lesions.