Based On The Investigation Of Clinical Cases Of Severe Acute Respiratory Infections In Shandong Province From 2016 To 2019

Background: Acute Respiratory Infection(ARI)is the main cause of death in infants and children with respiratory tract infection.Its pathogens are transmitted through droplets and contact,which can indirectly infect a large number of adults at the same time.It is also life-threatening to some patients.Due to its characteristics of easy mutation and simple transmission route,it has caused regular “flu pandemics” around the world.Severe acute respiratory infection(SARI)is used to describe ARI cases that require hospitalization during the influenza season.Nearly two million SARI cases die each year,and developing countries account for 70% of the total deaths.In recent years,there have been a number of large-scale SARI public health emergencies around the world,such as SARS in 2003,H1N1 in 2009 and H7N9 in 2013,and the worldwide outbreak of Corona Virus Disease 2019(COVID-19).These epidemics have caused serious negative impacts on the economic development and social life of countries around the world.Objective: To understand the basic composition,physical signs,main diagnosis and basic medical history and other data characteristics of SARI cases in Shandong Province,analyze the time distribution trend and pathogenic composition of SARI surveillance cases,and provide corresponding diagnosis,treatment and guidance for SARI surveillance cases based on the data,and provide a richer basis and side breakthroughs for the basic research of respiratory diseases.Methods: According to the sentinel surveillance plan for Inpatient SARI cases,the research team screened out 1146 patients who met the SARI surveillance standards from January 2016 to mid-June 2019 in the Affiliated Central Hospital of Jinan,and collected basic information,physical signs,main diagnoses,basic medical history,positive influenza virus results,etc.According to the situation,the hospital information system(HIS)is used to organize and summarize the cases,and the monitoring department is contacted for on-site investigation,and the data of some cases is improved.Finally,SPSS 20.0 is used for statistical analysis.Results: There were 1146 cases that met the SARI standard in the pediatric ward,respiratory medicine ward and ICU ward of Jinan Central Hospital from January 2016 to June2019.(1)The number of Flu A positive was 23 cases,and the number of Flu B positive was30 cases in SARI.There were no case of mixed infection of type A and type B.(2)The detection rates of influenza A and B viruses in male and female SARI patients were similar,which was further interpreted as not statistically significant.(3)The symptoms of SARI patients were mostly to possess with cough,expectoration,sore throat,and runny nose.In comparison,the incidence of cough(53.3%)and sore throat(32.5%)was higher in male patients,which was considered as statistical significance(p = 0.030;p = 0.031).(4)The highest proportion of patients was in the age group of 5-7 years.(5)In terms of outbreak trend,the data indicate that the number of SARI cases was generally decreasing,while the detection rate of influenza virus did not decrease simultaneously from 2016 to 2019.(6)Flu A was the crucial detection type of influenza virus in 2016,Flu A and Flu B were detected alternately in2017,Flu B was the major detection type in 2018,and Flu B was detected in 2019.(7)The high incidence period of positive influenza virus detection in SARI cases was 1-3 months and it was statistically significant(p = 0.001).(8)In terms of clinical diagnosis,bronchitis and sepsis were statistically significant between positive and negative influenza cases(p = 0.003;p = 0.024).(9)There were more cases of SARI with hypertension,coronary heart disease,and diabetes over 65 years old.Statistical analysis shows that there is a significant difference between diabetes and influenza virus infection among elderly patients(p = 0.006).(10)In terms of physical signs and body temperature,the results of influenza virus detection and the patient’s BMI and the highest body temperature during the course of the disease were not statistically significant.(11)In terms of medication,the usage rate of neuraminidase inhibitors in the treatment of clinical respiratory tract infections was relatively low,and there was no significant difference in the choices of medications and whether SARI cases have influenza.