| Objective:Through a questionnaire survey of people at high risk of postmenopausal osteoporosis.Record the general condition of the research object,TCM syndromes,bone density,bone metabolism indicators,bone turnover biochemical markers and other test indicators,and carry out relevant TCM syndrome differentiation on the research subjects.To explore the distribution characteristics of TCM syndromes in postmenopausal patients with osteoporosis and its relationship with biochemical markers of bone turnover.In order to carry out early diagnosis,intervention,strengthen prevention,and improve curative effect,further explore the advantages of traditional Chinese medicine in preventing and treating postmenopausal osteoporosis,and provide an objective basis for the diagnosis and treatment of integrated traditional Chinese and western medicine.Methods:The subjects of this study are those who participated in the questionnaire survey from November 2017 to December 2018 and met the inclusion criteria.Record the patient’s general information,fill in the TCM syndrome questionnaire,osteoporosis-related syndrome table and other evaluation scales.The dual-energy X-ray absorptiometry was used to measure the bone mineral density of the distal third of the radius,the first to fourth lumbar vertebrae and the hip joint.Detection of serum osteocalcin,serum type I procollagen N-terminal propeptide,serum type I collagen C-terminal peptide cross-linking and other indicators.Perform statistical analysis on TCM syndrome types,general data,and biochemical markers of bone turnover.Results:①Among the 202 patients included,44 people were in the normal bone mass group,57 people were in the osteopenia group,and 101 people were in the osteoporosis group,accounting for 21.8%,28.2%and 50.0%respectively.②In terms of age and menopausal years,the osteopenia group was higher than the normal bone mass group(P<0.05),and the osteoporosis group was higher than the normal bone mass group(P<0.05).At the age of menopause,there was no statistical significance between the normal bone mass group,the osteopenia group and the osteoporosis group(P>0.05).On BMI,the osteoporosis group was lower than the normal bone mass group and the osteopenia group(P<0.05).③In the osteoporosis group,there were 40 patients with spleen and kidney yang deficiency,44 patients with liver and kidney yin deficiency and 17 patients with qi stagnation and blood stasis type,accounting for 39.6%,43.6%and 16.8%respectively.④In terms of age distribution,there is no statistical significance among the three groups of syndrome types(P>0.05).At the age of menopause,the spleen and kidney yang deficiency type is smaller than the liver and kidney yin deficiency type(P<0.05).In terms of the number of years of menopause,the spleen and kidney yang deficiency type is higher than the liver and kidney yin deficiency type(P<0.05).In BMI,the spleen and kidney yang deficiency type is lower than the qi stagnation and blood stasis type(P<0.05).⑤In terms of serum osteocalcin(0C),the level of spleen and kidney yang deficiency type is higher than that of liver and kidney yin deficiency type(P<0.05).In serum type I procollagen N-terminal propeptide(PINP),the level of spleen and kidney yang deficiency type was higher than that of liver and kidney yin deficiency type and Qi stagnation type and blood stasis type(P<0.05).In serum type I collagen C-terminal peptide cross-linking(β-CTX),there was no statistical significance among the three groups of syndrome types(P>0.05).Conclusions:①The age and years of menopause are positively correlated with the prevalence of postmenopausal osteoporosis.The older and the longer the age of menopause,the more susceptible to.osteoporosis.②PMOP patients have lower BMI,the higher BMI is beneficial for maintaining bone density.③Among PMOP patients,the liver and kidney yin deficiency type is the most common,and the qi stagnation and blood stasis type is the least common.④Among the three TCM syndrome types of PMOP patients,the levels of OC,PINP and β-CTX in the spleen and kidney yang deficiency type are higher than those in the liver and kidney yin deficiency type and qi stagnation and blood stasis type,suggesting that the spleen kidney yang deficiency type has a faster bone turnover rate. |
