Clinical Observation Of Qizhi Dihuang Decoction In Improving Hypercoagulable State Of Idiopathic Membranous Nephropathy

Objective: To observe the clinical efficacy and safety of Qizhidihuang decoction in improving hypercoagulable state of adult idiopathic membranous nephropathy(qi deficiency and blood stasis syndrome),and to provide a new idea for the treatment of adult idiopathic membranous nephropathy hypercoagulability with integrated traditional Chinese and western medicine and to prevent the occurrence of thromboembolism.Methods:64 patients meeting the inclusion criteria were collected and randomly divided into the experimental group(n=32)and the control group(n=32)by SPSS random number table.The control group was given basic Western medicine treatment,and the experimental group was given Qizhidihuang decoction on the basis of the treatment of the control group.The clinical observation period was 8 weeks.Observed two groups of patients with blood clotting composite index(CI),activated partial prothrombin time(APTT),fibrinogen(Fib),24 hours urinary protein quantitative(24h UP),plasma albumin(propagated),D-dimer(D-D),total cholesterol(TC),triglyceride(TG),TCM syndrome integral,compare the difference between group and group,statistical analysis and safety evaluation.Results: 1.CI,APTT,FIB,D-D: APTT was increased in 2 groups after the test compared with before the test,while CI,FIB,D-D were decreased compared with before the test,with statistical significance in intra-group comparison(P<0.01),and the effect of increasing APTT,decreasing CI,FIB,D-D in the test group was better than that in the control group(P < 0.05).2.24 h UP and ALB: After the test,the 24 h UP of patients in both groups was decreased compared with before the test,and the ALB was increased compared with before the test,with statistical significance(P < 0.01)for intra-group comparison,and the effect of increasing ALB in the test group was better than that in the control group(P < 0.05),while the effect of reducing 24 h UP in the two groups was not statistically significant(P > 0.05).3.TC and TG: After the test,TC and TG in 2 groups decreased compared with before the test,with statistical significance in intra-group comparison(P < 0.01),and the effect of reducing TC and TG in the test group was better than that in the control group(P < 0.05).4.Clinical efficacy: the remission rate of clinical disease was 90.32% in the experimental group and 70.00% in the control group.The efficacy of the experimental group was better than that of the control group(P < 0.05).5.TCM syndrome score and efficacy: after the experiment,the scores of both groups were decreased compared with those before the experiment,and the intra-group comparison was statistically significant(P < 0.01),while the inter-group comparison was statistically significant(P < 0.05).The total effective rate of TCM syndromes was 87.09% in the experimental group and 73.33%in the control group(P < 0.05).6.Safety: After treatment,there was no significant abnormality in vital signs,blood routine,urine routine,stool routine,liver and kidney function,ECG and other aspects of patients in the two groups.During the treatment,2 patients in the control group developed mild nausea and vomiting,and the symptoms disappeared after symptomatic treatment with metoclopramide.Conclusion:Qizhidihuang decoction can effectively improve the Hypercoagulable state of patients with idiopathic membranous nephropathy,increase the level of serum albumin,reduce albuminuria,improve lipid metabolism,with definite curative effect and safe method.