Clinical Observation Of Xie He Decoction And Mindfulness Meditationin Treatment Of Kidney Deficiency And Liver Depression Patients Aged 18 To 24 Years With PCOS-IR

Objective:Based on the bio-psycho-social medical model,the purpose of this study is to explore the clinical effect of Mindfulness Meditation as an auxiliary means of drug treatment on improving the kidney deficiency and liver depression patients aged 18 to 24 years with PCOS-IR.Meanwhile,evaluating the clinical application value of Xie He Decoction combined with Mindfulness Meditation in the treatment of PCOS-IR by sorting out and analyzing the clinical data,so as to provide new ideas for the treatment of this disease and improve the clinical efficiency.Method:Selecting patients between the age of 18 and 24 who visited gynecological department of Jiangsu Province Hospital of Chinese Medicine from January 2020 to December 2020 that diagnosed as PCOS-IR and who had no reproductive needs for two years,with mild or above stress,anxiety or depression,and syndrome of liver depression and kidney deficiency.Sixty selected patients were respectively divided up into treatment group and control group(30 patients each)by adopting real world clinical research.The control group only given Xie He Decoction orally.The treatment group given Xie He Decoction combined with Mindfulness Meditation that include breath training and meditation training,which requiring patients to practice 15 minutes every night for 12 weeks as a course of treatment.Sex hormone levels(LH、FSH、E2、T、SHBG、PRL),Depression Anxiety Stress Scale score(DASS-21),TCM syndrome score,glucose and lipid metabolism index((FPG,FINS,HOMA-IR,BMI,WHR),and safety index were observed respectively at the initial diagnostic phase and twelve weeks after treatment.Results:(1)Scores of TCM symptoms:The total scores of TCM symptoms from both groups have obviously decreased(P<0.01).The treatment group significantly improved in menstrual cycle,plumpness,irritability and insomnia,while the control group improved in menstrual cycle,menstrual volume and plumpness.As shown(P<0.05),the difference was statistically prominent.In comparison of the control group,the treatment group performed better in terms of improving the total scores of TCM syndrome,menstrual cycle,irritability,insomnia and dreaminess,the difference was statistically significant(P<0.05).(2)Sex hormone level:Compared within the group,the level of T,SHBG,LH/FSH and LH were efficiently improved in both groups,the difference was significant in terms of statistics(P<0.01,P<0.05).The level of E2 also increased within the treatment group,the difference was statistically significant(P<0.05),although the level of E2 in the control group enhanced,but the difference was not statistically significant(P>0.05).Compared with the control group,the treatment group performed more effectively in reducing T,LH,LH/FSH and increasing SHBG,the difference was statistically significant(P<0.05).The efficacy of FSH,E2 and PRL were similar between the control and the treatment group,and the difference was not statistically significant(P>0.05).(3)Glucolipid metabolism level:Compared within the two groups,the treatment group effectively improved the level of FINS,FPG,HOMA-IR,BMI and WHR,the difference was statistically significant(P<0.01,P<0.05).In the meantime,FINS,HOMA-IR,BMI and WHR were more or less improved within the control group(P<0.05).Nevertheless,the difference for FPG was not statistically significant(P>0.05).Compared with control group,treatment group had better effect on improving FPG(P<0.05).The improvement of FINS,HOMA-IR,BMI and WHR was similar between two groups,but the difference was not statistically significant(P>0.05).(4)Depression Anxiety Stress Scale score:Compared within the group,the pressure and anxiety of treatment group were remarkably improved,as the difference was statistically significant(P<0.01),while the improvement of depression was not obvious,and the difference was not statistically significant(P>0.05).Compared with the control group,the treatment group was more significant in relieving stress and anxiety,and the difference was statistically significant(P<0.01).There was no significant difference in terms of relieving depression between the two groups(P>0.05).(5)Comprehensive curative effect:The effective rate of the control group resembles that of the treatment group,and the difference was not statistically evident(P>0.05).Conclusion:(1)The therapeutic effects of Xie He Decoction combining Mindfulness Meditation for the treatment of the kidney deficiency and liver depression patients aged 18 to 24 years with PCOS-IR is equivalent to Xie He Decoction alone.Compared to drug treatment alone,the treatment of body and mind can relieve the stress and anxiety more effectively,improve the TCM syndrome score and FPG,reduce the level of LH,T and increase the level of SHBG,which has good clinical intervention safety and worthy of promotion.(2)As an auxiliary method of traditional Chinese medicine treatment,Mindfulness Meditation has synergistic effect in regulating emotions,improving gonadal hormone concentrations,symptoms and glucolipid metabolism.