| Objective:To investigate the effects of "Kangshuanyihao" prescription on angina score,TCM syndrome score,endothelium related inflammatory factors and other indexes of patients with acute ST-segment elevation myocardial infarction(STEMI)after PCI.Methods:In this study,40 cases of STEMI patients with Qi-deficiency and blood-stasis syndrome who underwent emergency PCI were included.They were randomly segmented into the experimental group and the control group.The experimental group was treated with"kangshuanyihao" combined with standard Western medicine treatment,while the control group was treated with standard Western medicine treatment.After enrollment,the general information,angina pectoris score,TCM syndrome score,liver and kidney function and other indicators of each patient were recorded.The observation period of this study was set as 4 weeks,and the levels of serum NO,ET-1,SOD,MDA,IL-1β,IL-6 and TNF-α were detected after 1 week of treatment.After 4 weeks of treatment,angina pectoris score,TCM syndrome score,hematuria and feces routine,liver and kidney function test were performed again.At the same time,record whether there are major cardiovascular adverse events and other related adverse reactions in the course of treatment.Results:The comparison of baseline data between the two groups was not statistically significant(P>0.05).1.Score for angina pectoris:The quantitative scores of angina pectoris were 14.8±1.77 and 5.2±4.42 in the experimental group before and after treatment,and 15.8±1.44 and 8.0±4.26 in the control group,respectively.Before treatment,there was no significant statistical difference in the quantitative score of angina pectoris between the two groups(P>0.05).After 4 weeks of treatment,scores in both groups were significantly lower than before(P<0.05),and the decrease was even more pronounced in the experimental group(P<0.05).2.TCM Symptoms Score:TCM syndrome scores before and after treatment in the experimental group were 27.1±2.38 and 8.91±1.89,and those in the control group were 26.6±2.52 and 10.5±1.82,respectively.Before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05).After 4 weeks of treatment,both groups of TCM symptom scores have dropped significantly(P<0.05),and comparison between the two groups was statistically difference(P<0.05).3.Efficacy of TCM syndrome:After 4 weeks of treatment,the apparent efficacy was 35%ijn the experimental group and 5%in the control group.The two groups have significant differences in the apparent efficacy(P<0.05).4.Comparison of endothelium-associated inflammatory factors:(1)Comparison of endothelial function indicators:After 1 week of treatment,NO and ET-1 levels in the experimental group were 0.06±0.01 and 79.01±5.52,respectively,while those in the control group were 0.09±0.01,and 87.28±5.79.Visible experimental ET-1 were significantly lower than the control group,with statistical difference(P<0.01).However,NO level in experimental group was also lower than that in control group.(2)Comparison of oxidative stress indexes:After 1 week of observation,the serum SOD and MDA levels of experimental group were 14.57±3.62 and 10.60±3.79,respectively,while those of control group were 4.54±1.50 and 17.98±3.41,respectively.Experimental SOD level compared with the control group obviously higher(P<0.01),and the MDA level in experimental group was obviously lower than that in control group.(3)Comparison of inflammatory cytokines:After 1 week of treatment,serum levels of IL-1β,IL-6 and TNF-a in experimental group were 193.04±28.12,13.08±2.92 and 11.06±4.50,respectively,while the levels of IL-1β,IL-6 and TNF-α in control group were 300.29±32.02,24.17±4.35 and 30.59±5.93,respectively.Visible experimental inflammatory indexes were significantly lower than the control group,and the difference was statistically significant(P<0.01).5.Ad verse Reactions and MACE:During the observation period,there was no significant impairment of liver and kidney function in both groups.In the experimental group,3 cases were positive for urine occult blood and 1 case was positive for fecal occult blood.In the control group,1 case was positive for urine occult blood and 1 case was positive for fecal occult blood,with no statistical significance(P>0.05).And no patients with acute heart failure,malignant arrhythmia and other MACE.Conclusion:"Kangshuanyihao"+standardized treatment of Western medicine can effectively alleviate the angina symptoms of STEMI patients,reducing TCM symptom scores.It can significantly reduce the levels of serum ET-1,MDA,IL-1β IL-6,TNF-α and further increase the level of serum SOD,but can not significantly increase the level of serum NO.In addition,it does not increase the occurrence probability of MACE,and no adverse reactions such as impaired liver and kidney function were found,indicating good safety. |
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