The Clinical Research On The Effect Of Guanxinping Tablets On VEGF,bFGF In Elderly Patients Of Stable Coronary Artery Disease With Carotid Plaque

Objective:Observing the changes of clinical symptoms、electrocardiogram、VEGF and bFGF contents in serum、C-IMT and Crouse scores before and after treatment with Guanxinping in elderly patients of SCAD with carotid plaque combined with deficiency of Qi-Yin and Phlegm-Blood stasis syndrome.Then evaluating clinical effects and exploring the effective mechanism from the perspective of angiogenesis.Methods:From May 2020 to November 2020,60 elderly patients of SCAD with carotid plaque combined with deficiency of Qi-Yin and Phlegm-Blood stasis syndrome were enrolled in the study from Jiangsu Province Hospital of Chinese Medicine.They were all given orally basic western medicine and randly divided into the treatment group(combined with Guanxinping tablets)and the control group(combined with Yixinshu tablets).The course of treatment was 3 months.before and after treatment,the clinical symptoms、ECG、VEGF and bFGF contents in serum、C-IMT and Crouse scores of the above-mentioned groups were recorded and analyzed.Results:1.The efficacy of angina pectoris:After treatment,the angina symptom scores of two groups were markedly decreased(P<0.01),the decline of Guanxinping group was even greater(P<0.05);the frequency of attack and duration of angina pectoris in the above-mentioned groups were both markedly decreased(P<0.01),the decline of Guanxinping group was even greater(P<0.01).2.The efficacy of ECG:The total effective rate of two groups was 60.00%and 83.33%,the Guanxinping group achieves better result(P<0.05).3.The comprehensive efficacy of SCAD:The total effective rate of two groups was 53.33%and 80.00%,the Guanxinping group achieves better result(P<0.05).4.Symptom quantification of TCM:After treatment,the TCM syndrome scores of the two groups were markedly decreased(P<0.01),the decline of Guanxinping group was even greater(P<0.01).The total effective rate of the above-mentioned goups was 66.67%and 90.00%,the Guanxinping group achieves better result(P<0.05).5.C-IMT and Crouse scores:After treatment,C-IMT and Crouse scores of the two groups were markedly decreased(P<0.01),no statistical difference exists in the above-mentioned groups(P>0.05).6.VEGF and bFGF contents in serum:After treatment,the contents of VEGF in serum of the two groups were markedly decreased(P<0.01),the decline of Guanxinping group was even greater(P<0.01);The contents of bFGF in serum of the above-mentioned groups were markedly decreased(P<0.01),the decline of Guanxinping group was even greater(P<0.05).Conclusion:1.Guanxinping can improve the severity of angina pectoris、abnormal ECG、C-IMT and clinical symptoms of TCM of elderly patients of SCAD with carotid plaque combined with deficiency of Qi-Yin and Phlegm-Blood stasis syndrome.It is effective,safe and reliable.2.Guanxinping can significantly reduce the levels of VEGF and bFGF in serum of the above-mentioned patients.It is speculated that it may inhibit the angiogenesis in the plaque by lowing the expression of vascular growth factor,and play a role in stabilizing the plaque.It is one of the possible effective mechanisms of Guanxinping in the treatment of these persons.