Clinical Observation Of Huatan Tongluo Prescription In The Treatment Of Wind-phlegm-stasis Type Ischemic Stroke (Acute Phase)

Objective: To observe the effect of Huatan Tongluo Recipe in the treatment of wind-phlegm-stasis type ischemic stroke(acute stage)and its effect on serum superoxide dismutase(SOD)and malondialdehyde(MDA)levels,exploring the clinical efficacy and possible mechanism of Huatuntongluo prescription,and to provide more scientific and practical basis for its extensive clinical application.Observation phlegm treating t2 dm soup wind phlegm and blood stasis resistance in patients with ischemic stroke(acute)effects,and the serum superoxide dismutase(SOD)and malondialdehyde(MDA)levels,to discuss the clinical curative effect of phlegm know luo decoction and its possible effect mechanism,to phlegm t2 dm soup is widely applied in clinical provide more scientific practice basis.Methods: A total of 60 patients with wind-phlegm-stasis ischemic stroke(acute stage)meeting the inclusion criteria were randomly divided into control group and treatment group,with 30 patients in each group,according to the established diagnostic criteria of traditional Chinese and Western medicine.The control group received conventional medical treatment,and the treatment group received conventional medical treatment + Huatan Tongluo Decoction for 2 consecutive weeks.The changes of total TCM symptom score,TCM curative effect,clinical curative effect,neurological deficit score(NIHSS),ADL score,serum superoxide dismutase(SOD)and malondialdehyde(MDA)contents in 2 groups before and after treatment were observed.Results:(1)TCM syndrome score: after treatment,both groups could improve TCM syndrome score of patients with ischemic stroke(P < 0.05);The improvement of scores in treatment group was significantly better than that in control group(P < 0.05).(2)Therapeutic effect of traditional Chinese medicine: the effective rate of the treatment group was 93.33%,significantly better than that of the control group(68.97%).(3)Clinical efficacy: The total effective rate of the treatment group was96.67%.The total effective rate of the control group was 86.21%,and the clinical efficacy of the treatment group was significantly better than that of the control group,the difference was statistically significant(P<0.05).(4)NIHSS score: The comparison of NIHSS score before treatment between the two groups(P > 0.05)showed no statistical significance.After treatment,both groups could improve the NIHSS scores of patients with neurological impairment,and the therapeutic effect of the treatment group was better than that of the control group(P < 0.05),the difference was statistically significant.(5)Daily living ability scale(ADL): there was no significant difference in ADL scores between the two groups before treatment(P > 0.05);After treatment,ADL scores of patients with ischemic stroke were improved in both groups(P < 0.05),and the treatment group was better than the control group(P < 0.05).(6)Blood indexes: there was no significant difference in serum SOD and MDA between the two groups before treatment(P>0.05).After treatment:SOD content in treatment group was significantly increased,MDA content was significantly decreased,compared with control group,the difference was statistically significant(P < 0.05).Conclusions:Huatan Tongluo Decoction has a significant effect in the treatment of ischemic stroke(acute stage)with wind-phlegm-stasis type,with high safety and few adverse reactions.The mechanism of effective improvement of TCM syndrome score,NIHSS score and ADL score in patients may be related to the effect of Huatan Tonglu Decoction on increasing SOD level,reducing MDA content,and participating in the regulation of oxidative stress process.