| Objective:To analyze the basic condition and etiological composition of acute pancreatitis(AP)patients in Yanbian area,and to explore the factors associated with the severity of the disease,in order to provide reference for the early prevention of AP in Yanbian area,as well as to reduce the incidence of AP and its criticality,so as to improve the prognosis of patients.improve the prognosis of the patients.Methods:A total of 1241 AP patients hospitalized in the Affiliated Hospital of Yanbian University from January 2015 to December 2020 were collected,and the general information,underlying diseases,length of hospitalization,hospitalization expenses,laboratory examinations of 696 patients who met the inclusion criteria were retrospectively analyzed.Results:1.From January 2015 to December 2020,the number of cases of AP patients showed an overall increasing trend by year.Among them,238 cases(34.2%)were MAP,255 cases(36.6%)were MSAP,and 203 cases(29.2%)were SAP.In 2015,SAP was less than MSAP,and in 2020,SAP was more than MAP and MSAP(P<0.05).2.There were more males than females in AP patients,with a male-to-female ratio of2.03:1.The average age was 51.53±16.71 years old,with patients >60 years old being the most common(31.8%),and the average age of females was higher than that of males.Han nationality was more than Korean nationality,and the ratio of Korean to Han was 9:16.3.The primary cause was biliary(33.2%),followed by alcoholic(17.8%),idiopathic(17.0%),over-eating(11.9%),hypertriglyceridemic(9.8%),multiple etiologies(6.2%),and other etiology(4.2%).The combination of alcohol and hypertriglyceridemia(alcohol-fat)accounted for the largest proportion of multiple etiologies(72.1%).The biliary,alcoholic and other etiology showed downward trends,while the hypertriglyceridemic,over-eating,idiopathic and multiple etiologies showed upward trends.4.The proportion of biliary etiology in female patients(50.4%)was more than that in male patients(24.7%),while the proportion of alcoholic(24.7%)and multiple etiologies(8.8%)in male patients were more than that of alcoholic(3.9%)and multiple etiologies(0.9%)in female patients(P < 0.05).Biliary etiology was the most common in both Korean and Han nationality,there was no statistical difference between the etiology and nationalities(P>0.05).5.The average age of hypertriglyceridemic group was the youngest(40.44±13.18 years old)and the biliary group was the oldest(62.11±15.34 years).In biliary patients,> 60 years old group was more than other age groups.In alcoholic,hypertriglyceridemic,over-eating,multiple etiologies patients,≤60 years old group was more than >60 years old group.All differences were statistically significant(P<0.05).6.MAP was more than SAP in biliary etiology,SAP was more than MAP in hypertriglyceridemic etiology(P < 0.05).Hypertriglyceridemic etiology was most likely to become severe,followed by multiple etiologies and idiopathic,over-eating was the least likely to become severe.Among the multiple etiologies,alcohol-fat was the most likely to become severe.7.AP complicated with diabetes or fatty liver,and the elevation of hemoglobin,triglycerides,C-reactive protein on admission were more likely to become severe(P<0.05).The length of hospitalization and hospitalization expenses paralleled to the severity(P<0.05).Conclusions:1.The primary cause of AP in Yanbian area was biliary,followed by alcoholic and idiopathic.2.Biliary was more common in the elderly,alcoholic,hypertriglyceridemic,over-eating,and multiple etiologies were more common in the young and middle-aged.Biliary etiology was the most common in both Korean and Han nationality.3.The top three causes of AP prone to become severe are hypertriglyceridemic etiology,multiple etiologies and idiopathic.4.The factors positively correlated with the severity of AP were complicated with diabetes or fatty liver,and the elevation of hemoglobin,triglycerides,C-reactive protein on admission. |
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