An Analysis Of Clinical Value Of CAR And SII In Patients With Non-small Cell Lung Cancer

Objective:The aim of research is to investigate the relationship between c-reactive protein/albumin(CAR),systemic immune-inflammation index(SII)and clinicopathological characteristics of patients with non-small cell lung cancer.And the changes of these indicators before and after chemotherapy,to explore whether these indicators can provide help for the evaluation of the condition and efficacy of patients with NSCLC.Methods: From September 2017 to October 2020,through the collection of the clinical data of 118 patients with NSCLC(age,gender,smoking history,side,pathological type,clinical stage,tumor chemotherapy regimens,PS score,c-reactive protein,albumin,blood platelet count,neutrophil count,lymphocyte count)who admitted to the first affiliated hospital of Wannan Medical College in the department of Respiratory Medicine and Thoracic Surgery.Patients were divided into high and low CAR group,high and low SII group according to the median to analyze the relationship between CAR,SII and clinicopathological characteristics of NSCLC patients.After that,CAR and SII levels of patients with advanced NSCLC were compared before and after chemotherapy in different therapeutic groups.SPSS25.0 was used for statistical analysis.Results:1.Comparison of CAR and SII in sex,age,smoking history,tumor side,pathological type and CEA group,There was no statistically significant difference.There was statistical significance in staging,lymph node metastasis degree and PS score(P < 0.05).CAR and SII levels of the IV stage were higher than those of the patients in the I and II stage,CAR level of the patients in the III stage was higher than that in the I and II stage,and the differences were statistically significant(P < 0.05).2.There were significant differences in staging,lymph node metastasis and PS score between the high CAR group and the low CAR group(P < 0.05),also in the SII group.There were no significant differences in other clinical features between the two groups(P>0.05).3.With the gradual increase of stage of NSCLC patients,CRP showed a gradually increasing trend(P<0.001),ALB showed a gradually decreasing trend(P=0.014),CAR showed a gradually increasing trend(P < 0.001).PLT showed a gradually increasing trend(P=0.007),NEUT showed a gradually increasing trend(P<0.001),SII showed a gradually increasing trend(P<0.001),and the differences were statistically significant.4.In the effective group of patients with advanced NSCLC,the levels of CAR and SII after chemotherapy decreased statistically compared with those before treatment(P<0.05).In the ineffective group,CAR levels increased after chemotherapy compared with before treatment,But the difference was not statistically significant(P=0.394),The level of SII increased after chemotherapy,which was statistically significant compared with that before treatment(P=0.046).5.The areas under ROC curve of CAR and SII were 0.839 and 0.775,The sensitivity was 69.8% and 60.5%,The specificity was 84.4% and 87.5%.Conclusion: 1.CAR and SII were correlated with stage,degree of lymph node metastasis and PS score of NSCLC patients.CAR and SII are larger as staging gets later.2.CAR,SII were differences in early and advanced NSCLC,which are helpful for clinical assessment and prediction.