Clinical Analysis Of 358 Inpatients With Henoch-Schonlein Purpura

Objective: To analyze the differences in the general conditions,epidemiological characteristics,clinical features,laboratory indicators,treatment plans,and treatment outcomes of 358 inpatients with Henoch-Schonlein Purpura(HSP),and the related risk factors for kidney damage.Providing reference for clinical work.Methods: Collecting clinical data of patients with HSP who were hospitalized in our dermatology department from April 1,2016 to December 31,2020.Dividing them into groups according to age: children group(age<18 years old)and adult group(age ≥18years old);then dividing into two groups according to whether there was renal damage:renal damage group(92 cases)and non-renal damage group(266cases).Retrospectively analyze the clinical data of each group of patients,and compare the differences in general conditions,epidemiological characteristics,clinical features,laboratory indicators,treatment plans and treatment outcomes.Results:1.The peak incidence of HSP are in autumn and winter;The respiratory tract infection in the children group before the onset of HSP is more common,and the difference is statistically significant compared with the adult group(P<0.05);Renal damage is more common in adult than in children,and the difference between the two groups is statistically significant(P<0.05);The non-renal damage group had a higher proportion of respiratory tract infection,the difference was statistically significant(P<0.05).2.The rash on both lower limbs is most common in HSP patients;The simple type is the most clinical type,and the joint type is more common in children;The adult group was more likely to have gastrointestinal symptoms and kidney damage,and the difference between the two groups was statistically significant(P<0.05);The renal damage group was prone to abdominal pain and gastrointestinal bleeding,and the difference is statistically significant compared with the non-renal damage group(P<0.05).3.The proportion of adult group with elevated PLT,CRP,ESR,m ALB and 24-h urine protein,decreased ALB,microscopic hematuria positive,proteinuria positive,and fecal occult blood positive was higher than that in children group,the differences were statistically significant(P<0.05).The average SCR,BUN,m ALB,24-h urine protein,CRP and ESR levels of HSP patients in adult group were higher than those of children group,and the PLT level were lower than that of children group,and the differences were statistically significant(P<0.05).The average SCR,CRP,ESR,24-h urine protein and m ALB levels in renal damage group were higher than those of non-renal damage group,and the ASO and PLT levels were lower than those of non-renal damage group.All were statistically significant(P<0.05).4.Adult group and renal damage group used more glucocorticoids and Immunosuppressants,the differences were statistically significant(P<0.05).5.There was no significant difference of the average hospitalization time between children group and adult group(P>0.05).The difference of the average hospitalization time between renal damage group and non-renal damage group was statistically significant(P<0.05).The treatment outcomes in adult group were worse than that in children group,the difference was statistically significant(P<0.05).Renal damage group had worse treatment outcomes than non-renal damage group,the difference was statistically significant(P<0.05).6.Age over 18 years old(OR=2.360)is independent risk factor for kidney damage in patients with HSP.Conclusions:1.HSP is more common in children than in adults;upper respiratory tract infection is the most common cause.2.Children are more likely to have joint symptoms,and adults are more likely to have gastrointestinal symptoms and kidney damage.3.Adult group and renal damage group are more likely to have abnormalities in laboratory indicators such as SCR,CRP,ESR,and 24 h urine protein.4.The treatment of patients with HSP in the adult group and the renal damage group is more complicated,using more glucocorticoids and immunosuppressants,the hospitalization time was longer,and the treatment outcomes were poorer.5.Age over 18 years old is the independent risk factor for kidney damage in patients with HSP.