Research On Insomnia Based On Ancient Literature

Objective To explore the etiology and pathogenesis of insomnia in ancient medical books(late Qing Dynasty before 1911),and explore the rule of syndrome and treatment rules of insomnia combined with ancient medical cases,so as to provide reference for clinical treatment of insomnia in modern Chinese medicine.Methods Referring to the late Qing Dynasty before the insomnia of ancient literature,in the principle of no word without a place,to the ancient insomnia related literature review,combing,induction,analysis,clear the cause of insomnia.By using bibliometric analysis method,the strict inclusion criteria of insomnia medical prescriptions were established and a prescription database was established.With the help of "traditional Chinese Medicine Inheritance computing platform V3.0",the prescription database was established.By using association rule analysis and K-means algorithm,This paper attempts to find the core drugs,high-frequency drug pairs and potential core prescriptions of ancient insomnia medical records,and explore the law of syndrome differentiation and treatment of insomnia.Result 1.Select the ancient refined text to discuss,summarize the 13 major causes of insomnia,such as exogenous six evils,Pandora Qi,seven emotions internal injury,improper diet,living disorders,pathological products,overwork,etc.Insomnia pathogenesis is intricate and complex,but the total is nothing more than Yang does not enter Yin,Yin and Yang lose cross,disturbed by the mind,the disease is mainly in the heart,but not rigidly in the heart.It is closely related to the pathological changes of spleen,kidney,liver,gallbladder,stomach and Qi,blood,yin and Yang.Total 23 types of insomnia syndrome were excavated,and the ancient and modern medical cases,prescriptions,and Professor Zhang Guangji’s insomnia medical cases were mutually verified.23 methods of calming the nerves were summarized,including nourishing yin and reducing fire,clearing heart and calming mind,resolving depression and resolving phlegm,strengthening gallbladder and calming mind,warming gallbladder and stomach,resolving phlegm and calming mind,strengthening spleen and stomach,harmonizing cold and heat,calming stomach,soothing liver and sleeping,purging fire and calming mind.It is suggested that all the five viscera organs can cause insomnia,and the pathogenesis of "disharmony between stomach and stomach can cause restlessness in bed" is played out.It is believed that the pathological changes of cold and heat caused by deficiency and solid condition of stomach and intestines can lead to gastric incompatibility and lead to insomnia,and seven specific pathogenesis of "disharmony between stomach" are put forward.2.In terms of bibliometric analysis,nearly 60 kinds of famous medical cases were involved,and a total of 391 prescriptions of insomnia medical cases were included,with a total of 2443 Chinese herbs and 14 core medicines were obtained,In the first-level classification of the efficacy of traditional Chinese medicine,drugs such as tonifying deficiency,clearing heat,tranquilizing the mind,improving water and moistening the body,regulating qi and reducing phlegm accounted for a large proportion.In the second level efficacy classification,Ningxin,Ningxin Anshen and Anshen Yizhi were the most important.The association rule analysis was used to get 25 core drug pairs,among which the most frequently used one was the combination of jujube kernel and fushen.Finally,the K-means algorithm was used to get four prescription combinations for clinical reference.Conclusion Summarizing the etiology and pathogenesis of insomnia is of great significance for the treatment of insomnia through the examination of causes and syndrome differentiation in Chinese medicine.There is a certain regularity in the prescription of insomnia in ancient medical books,and the characteristics of medication can be used for reference to enlighten the thinking of diagnosis and treatment of insomnia in modern Chinese medicine.Bibliometric analysis can get some relatively objective and quantitative results from different angles and different levels,which provides a certain basis for clinical research of insomnia.