Changes Of Elabela Levels In Patients With Heart Failure And Its Clinical Significance

Research background and purpose:Heart failure(HF)is a serious manifestation or late stage of various Heart diseases,with high mortality and readmission rates.Studies have shown that Elabela levels are increased in patients with heart failure,and Elabela’s protective effect in heart failure has been proven,suggesting that Elabela may be involved in the occurrence and outcome of heart failure.In this study,the correlation between serum Elabela level and severity of heart failure was analyzed by measuring the concentration of serum Elabela in patients with heart failure and the control group,and the clinical significance of serum Elabela in the diagnosis and severity assessment of heart failure was explored by measuring the concentration of serum Elabela about 1week after the treatment of heart failure.Method:A total of 101 patients were enrolled in the Department of Cardiovascular Medicine of the Second Hospital of Jilin University from July 2020 to November2020,including 69 patients in the heart failure group.Among them,19 patients were classified as Ⅱ patients according to NYHA cardiac function classification,27 patients were classified as Excellent patients,and 23 patients were classified as Grade I patients.The etiology of heart failure includes ischemic heart disease,dilated cardiomyopathy,valvular disease,and rheumatic heart disease.The diagnosis of heart failure is based on the "Diagnosis and Treatment of Heart Failure in China 2018".At the same time,32 patients who were admitted to our hospital due to ischemic heart disease,arrhythmia,hypertension,etc.,and were diagnosed as non-heart failure after examination of heart color ultrasound and N-terminal B-type natriuretic peptide precursors,etc.,and had no previous history of heart failure.Enzyme linked immunosorbent assay(ELISA)was used to detect serum Elabela concentration of selected patients.SPSS 26.0 software was used to analyze the serum Elabela level in different groups of patients,and the correlation between serum Elabela level and NT-pro BNP and LVEF was analyzed.Result:1.Compared with the control group,age,serum Elabela level,NT-pro BNP,hs-c Tn I,hs-c Tn I and serum Elabela level in the heart failure group were significantly higher than those in the control group.Hcy,CRP,BUN,UA and Cr were higher than those in the control group.LVEF was lower than control group(P < 0.05);2.With the increase of NYHA classification,serum Elabela level,NT-pro BNP level increased,and LVEF level decreased(P < 0.05);3.After standard treatment,serum Elabela level and NT-pro BNP decreased compared with admission(P < 0.05).;4.The linear correlation analysis showed that serum Elabela level in heart failure group was positively correlated with NT-pro BNP(r=0.506,P<0.05),negatively correlated with LVEF(r=-0.265,P=0.03);5.ROC analysis showed that the AUC for serum Elabela level was 0.96(95%CI:0.922-0.998)and the AUC threshold was 3486.29pg/ml(sensitivity was95.7%,specificity was 90.6%).Conclusion:1.In the present study,serum Elabela levels in 69 patients with heart failure in the experimental group were increased compared with those in the control group and decreased after standard drug treatment.2.Serum Elabela level was positively correlated with cardiac function grade and NT-pro BNP,and negatively correlated with LVEF,suggesting that it may be related to the severity of heart failure.3.Serum Elabela level in patients with heart failure may have some diagnostic value.