Clinical Research On Ⅳ Stage Of Diabetic Nephropathy (Spleen And Kidney Yang Deficiency With Stasis Toxin Syndrome) Treated By Warming And Moisturizing And Detoxification And Dredging Collaterals Method

Objective: To observe the clinical efficacy and safety of the method of warming moisture,detoxification and dredging collaterals in the treatment of IV stage of diabetic nephropathy(spleen and kidney Yang deficiency combined with stasis toxin syndrome).Methods: 72 patients with diabetic nephropathy were randomly divided into treatment group(n=36)and control group(n= 36).The methods of self-control and control group were taken before and after treatment.All the patients were given routine basic treatment,and the treatment group was treated with self-made warming moisture,detoxification and dredging collaterals decoction for 12 weeks.The changes of TCM syndrome score,24-hour urinary protein quantitation,serum creatinine,blood urea nitrogen serum albumin and glycosylated hemoglobin were observed and statistically analyzed before and after treatment.Results:(1)The total effective rate of the treatment group was 87.10%,which was better than that of the control group 56.67%(p<0.05).(2)The treatment group could improve chilly sensation and the cold limbs,frequent nocturnal urination,listless and asthenia,purple and dark lips,turbid urine and thin sloppy stool which was better than that of the control group(p<0.05).There was no significant difference between the treatment group and the control group in the treatment of soreness and weakness of waist and knees,limbs edema,restlessness,dry pharynx and mouth dryness.In terms of overall improvement of TCM symptoms,the treatment group was better than the control group(p<0.05).(3)The treatment group could reduce serum creatinine,blood urea nitrogen,24-hour urinary protein quantitation,glycosylated hemoglobin,and increase serum albumin,which was better than that of the contrdl group(P<0.05).Conclusion: The method of warming moisture,detoxification and dredging collaterals can improve the symptoms and signs of diabetic nephropathy in IV stage(spleen and kidney Yang deficiency combined with stasis toxin syndrome),reduce 24-hour urinary protein quantitation,blood urea nitrogen,serum creatinine and glycosylated hemoglobin,and increase serum albumin.No adverse reactions were found,and it is safe and reliable.