The Clinical Study Of Chai Xie Tang On Functional Dyspepsia Postprandial Discomfort Syndrome(Spleen Deficiency And Qi Stagnation Type)

Objective: to observe the clinical effect,recurrence and influence on quality of life of Chai Xie tang in treating functional dyspepsia(FD)postprandial discomfort syndrome(PDS)of spleen deficiency and qi stagnation,and enrich the TCM treatment of functional dyspepsia postprandial discomfort syndrome(FD-PDS)clinical basis.Methods: to divide 72 patients with FD-PDS of spleen deficiency and qi stagnation into two groups with 36 patients in each group.One group(mosapride group)was treated with mosapride citrate and the other group(Chai Xie group)was treated with Chai Xie Tang for 4 weeks.Then the single symptom score,clinical syndrome score,quality of life scale,relapse as well as safety index before and after treatment were observed aiming at evaluating the clinical efficacy and safety of Chai xie tang in treating FD-PDS(spleen deficiency and qi stagnation syndrome)by means of statistical analysis of data.Results: 61 cases in total were involved in this study.(1)Comparison of TCM symptom scores: Intra group comparison: both groups were treated,The Individual symptom fraction and clinical syndrome fraction of the two groups were better than before(P < 0.01).Intergroup comparison: both groups were treated,Chai Xie group was much better than mosapride group in promoting abdominal distension,abdominal distension and pain,symptoms of dementia and total score of syndromes(P < 0.01).when it comes to the effect in improving the symptoms of fatigue and weakness,Chai Xie group worked the same as mosapride group(P > 0.05).The mosapride group was not as good as the Chai Xie group in improving the symptoms of belching and loose stool(P < 0.05).(2)The contrast of clinical efficacy of TCM Syndrome: both groups were treated,The total effective ratio of one group(mosapride group)was 76.67% and the other group(Chai Xie group)was93.55%,which shows a statistical difference(P < 0.05).(3)The contrast of quality respect of life: Intra group comparison : both groups were treated,total fractions of quality respect of life scale for two groups and single score of every field were better than before(P < 0.01);Intergroup comparison: The total score of quality of life in Chai Xie group was significantly higher than that in mosapride group(P < 0.01).Both groups were treated,along with the fractions of daily life,the sense of health in the Chai Xie group were also evidently higher than those in the mosapride group(P < 0.01),and the scores of disease control and discomfort in the two groups were similar(P > 0.05),The scores of anxiety,sleep,diet and stress in the Chai Xie group were higher than those in the mosapride group(P < 0.05).(4)comparison of long-term effect: 4 weeks after treatment,the relapse rate of the mosapride group was 31.82% and 7.41% for the Chai Xie group,which was evidently lower than that of the mosapride group(P < 0.05).Conclusion: Chai xie tang can obviously improve the symptoms of epigastric fullness or distension and pain,dullness,belching,fatigue and loose stool in patients with FD-PDS of spleen deficiency and qi stagnation type,and can improve people’s quality of life,and has better long-term curative effect,the treatment of functional dyspepsia with traditional Chinese medicine(TCM)has its own characteristics and advantages,and is worth popularizing.