Correlation Between TCM Syndrome Differentiation Of Chronic Heart Failure And NT-proBNP,cTnⅠ,Serum Creatinine

Objective:In this study,the expression levels of NT-proBNP,troponin Ⅰ(cTn Ⅰ)and serum creatinine(Scr)in patients with chronic heart failure were detected to explore the relationship between laboratory indexes and TCM syndrome differentiation and cardiac function classification,so that the idea of syndrome differentiation and treatment can be more objective,and provide objective reference for TCM and TCM in the process of diagnosis and treatment.Methods:A cross-sectional study was conducted to select 200 patients with chronic heart failure hospitalized in the Affiliated Hospital of Changchun University of Traditional Chinese Medicine from December 2019 to December 2020.The clinical data of patients were collected and analyzed by SPSS25.0 statistical software.Results:1.Cardiac function classification:1.1 The basic situation of admission:The respiratory rate of cardiac function Ⅲ andⅣ group was significantly higher than that of cardiac function Ⅱ group,P<0.01;1.2 Echocardiography:Left ventricular ejection fraction in cardiac function class Ⅳgroup was significantly lower than that in cardiac function class Ⅱ group,P<0.01;The left ventricular end-diastolic diameter in the cardiac function Ⅳ group was significantly higher than that in the cardiac function Ⅱ group,P<0.01;1.3 Laboratory examination:NT-proBNP level comparison:cardiac function Ⅲ,Ⅳgroup was significantly higher than cardiac function Ⅱ group,P<0.01;cardiac function Ⅳgroup was higher than that of cardiac function Ⅲ group,P<0.05;Comparison of serum creatinine level:cardiac function class Ⅳ group was significantly higher than cardiac function class Ⅱ group,P<0.01;Cardiac function grade Ⅲ group was higher than cardiac function grade Ⅱ group,P<0.05;Comparison of positive rate of cTn Ⅰ:The cardiac function of grade Ⅲ and Ⅳ group was significantly higher than that of grade Ⅱ group,P<0.01.2.TCM syndrome differentiation:2.1 Basic information of admission:There was no significant difference in basic data(gender,age,body temperature,pulse,respiration,systolic blood pressure,diastolic blood pressure)between groups,P>0.05;2.2 Cardiac color Doppler ultrasound examination:Yang deficiency and blood stasis and water retention syndrome,Yin and Yang deficiency and blood stasis and water retention syndrome left ventricular ejection fraction was significantly lower than other syndrome groups,P<0.01;2.3 Laboratory examination:NT-proBNP level comparison:Yin and Yang deficiency,blood stasis syndrome was significantly higher than Qi deficiency and blood stasis syndrome,P<0.01;Qi deficiency and blood stasis syndrome with water decoction was higher than Qi deficiency and blood stasis syndrome,P<0.05;Comparison of serum creatinine levels:Yin and Yang deficiency,blood stasis syndrome was significantly higher than Qi deficiency and blood stasis syndrome,Qi deficiency and blood stasis syndrome,Qi and Yin deficiency,blood stasis syndrome,P<0.01;Yang deficiency and blood stasis syndrome is higher than Qi deficiency and blood stasis syndrome,P<0.05;Comparison of cTnI positive rate:Yin and Yang deficiency,blood stasis and water drinking syndrome,Yang deficiency and Qi deficiency and blood stasis and water drinking syndrome were significantly higher than other syndrome groups,P<0.01.3.Correlation analysis:NT-proBNP was significantly positively correlated with serum creatinine,r=0.535 P<0.01;Serum creatinine was significantly negatively correlated with left ventricular ejection fraction,r=-0.258 P<0.01.The left ventricular ejection fraction was significantly negatively correlated with NT-proBNP,r=-0.313 P<0.01.Conclusion:1.The respiratory rate,left ventricular end-diastolic diameter,NT-proBNP,and serum creatinine of patients with chronic heart failure gradually increased with the increase of cardiac function;left ventricular ejection fraction decreased gradually;The positive rate of cTn I was higher in cardiac function grade Ⅳ.2.The NT-proBNP,serum creatinine level,cTnI positive rate will be significantly increased,left ventricular ejection fraction will be significantly decreased when the syndrome of yang deficiency syndrome elements.3.NT-proBNP was positively correlated with serum creatinine;Left ventricular ejection fraction was negatively correlated with NT-proBNP and serum creatinine.4.NT-proBNP,serum creatinine,cTnI and other indicators can provide certain basis for TCM syndrome differentiation,disease prevention and treatment of chronic heart failure.