Observation Of OCT And Neutrophil/Nymphocyte Ratio In Acute And Remission Stage Of NMOSD

Objective:To observe and evaluate the changes of optical coherence tomography(OCT)and neutrophil-to-lymphocyte ratio in acute and remission stage of neuromyelitis optica spectrum disease(NMOSD).Metods: Thirty-nine patients diagnosed with neuromyelitis optica spectrum disease from September 2018 to January 2021 were collected,and 42 age-matched healthy controls were selected as the study subjects.Patients with NMOSD were followed up.Blood routine and optical coherence tomography(OCT)were used to quantitatively analyze and compare neutrophil/lymphocyte and monocyte/lymphocyte ratios,optic nerve fiber layer thickness and central macular thickness OCT.Results:There were significant differences in neutrophils/lymphocytes and monocytes/lymphocytes between patients with acute attack of NMOSD and healthy controls(P<0.05).There was no significant difference in neutrophils/lymphocytes between patients in remission stage and patients in acute stage before and after 3 months of follow-up(P<.05),which was lower than before.There was a significant difference in the temporal values of healthy patients with NMOSD,and there was a significant difference in the temporal RNFL thickness before and after 3months in patients at the detection level of P= 0.1,and there was no significant difference in the RNFL thickness between the definite remission stage and their own acute stage during follow-up.Compared with the healthy group,the thickness of each quadrant of NMOSD macula was significantly thinner,the volume was reduced,and the sensitivity of injury was reduced.However,there was no significant difference in macular thickness before and after 3 months and remission in follow-up patients between the two groups.Conclusion: NLR is helpful to assess markers of disease activity in NMOSD,and high MLR levels are intrinsic characteristic changes of the disease.RNFL thickness was significantly thinned in the temporal quadrant of the peripapillary RNFL.The thickness and volume of each quadrant of the macula were significantly reduced,and the sensitivity of the injury was reduced.