Association Of Traditional Chinese Medicine Constitution With Nonalcoholic Fatty Liver Disease In Community Elderly In Henan

ObjectivesIn order to provide new ideas and evidence for prevention of NAFLD,this study intends to explore the relationship between nonalcoholic fatty liver disease(NAFLD)and Traditional Chinese Medicine(TCM)Constitution Types and other influence factors among elderly people in Puyang,Henan Province.MethodsThe study included 3267 elderly people(≥65)who had participated in the 2019 physical examination in Huang he Road Community Health Service Center of Puyang.After strict inclusion and exclusion criteria,a total of 3180 subjects were finally included in this study.Staff who participated in the study were professionally trained to collect target information through questionnaires,physical examinations and laboratory tests.Constitution Types was estimated by the questionnaire form "Classification and Determination of TCM Constitution Types ",and Microsoft Excel was used to build a database and enter the data.The basic characteristics such as demographic factors,physical examination,and disease history were compared by Student’s t-test and chi-square test.Logistic regression models were applied to identify the relationship between NAFLD and TCM Constitution Types and other influence factors.The odds ratio and 95% confidence interval(OR(95% CI))were used for the assessment of influencing factors.Results1.A total of 3180 study subjects with an average age of 71.92(5.46)years old were included in this study.Among the population in the study,there were statistical differences in the distribution of TCM physique between NAFLD patients and non-patients of the total population,male and female(all P < 0.001).In the total population,phlegm-damp(61.9%),yin-deficiency(10.6%),yang-deficiency(10.5%),and calmness(6.5%)were more common in patients with NAFLD.Among men,phlegm-damp(71.3%),yang-deficiency(7.2%),yin-deficiency(6.6%),and calmness(5.9%)were more common in patients with NAFLD.Among women,phlegm-damp(56.7%),yin-deficiency(12.8%),yang-deficiency(12.3%),and calmness(6.8%)were more common in patients with NAFLD.2.After adjusting for age and gender covariates,the body types with higher prevalence in the total population in order were phlegm-damp,qi-stagnation,special-dampness,yin-deficiency;the body types with higher prevalence in the men in order were phlegm-damp,special-dampness,qi-stagnation,yin-deficiency;the body types with higher prevalence in women in order were phlegm-damp,damp-heat,qi-stagnation,and special-dampness.The differences in the prevalence of each TCM physique in the total population,men,and women were statistically significant(P <0.05).3.After adjusting for the covariates,the risk of phlegm-damp(OR:4.18,95%CI:1.58)and qi-stagnation(OR:1.58,95%CI:1.03-2.41)was higher in the total population,compared with the ideal body type of phlegm-damp;the risk of phlegm-damp(OR:3.98,95%CI:2.53-6.25)was higher in the men;the risk of phlegm-damp(OR:4.36,95%CI:3.04-6.25)and damp-heat(OR:2.56,95%CI:1.02-6.39)was higher in the women.4.Risk factor of NAFLD were discussed before the stratification analysis.In the total population,women,smoking,overweight,obesity,hypertension,and diabetes were risk factors for NAFLD disease;thinness and older age were protective factors for NAFLD disease.Among the men,smoking,alcohol consumption,overweight,obesity,hypertension and diabetes were found to be risk factors for the development of NAFLD;and age 70-80 years was protective factors for NAFLD disease.Among the women,overweight,obesity,hypertension,and diabetes were risk factors,and older age as well as low weight were protective factors.Among the women,overweight,obesity,hypertension,and diabetes were risk factors,and older age as well as low weight were protective factors.In the stratification analysis,the association of phlegm-damp and NAFLD was more pronounced among people who were overweight/obese,with a OR of 2.40(1.61,3.57).Conclusions1.In the population of community elderly,phlegm-damp,yin-deficiency,and yang-deficiency qualities are more frequent among patients with NAFLD;among the various TCM constitution,the prevalence of NAFLD is significantly higher in phlegm-damp than in other body types.2.TCM body type is associated with NAFLD prevalence in community elderly.In men,people with phlegm-damp have a high risk of NAFLD prevalence.In women,people with phlegm-damp and damp-heat have high risk of NAFLD prevalence.3.The association of phlegm-damp with NAFLD prevalence is more pronounced among people who are overweight/obese,...