Analysis And Application Research Of Constitution And Risk Factors In Patients With Nonalcoholic Fatty Liver Disease

Objective:In order to make the treatment of NAFLD more diversified,give full play to the advantages of traditional Chinese medicine,reduce the pain of patients,delay the course of disease,improve the prognosis,based on the theory "Preventive Treatment of Disease" of TCM,this study intends to analyze the relationship between TCM Constitution Types and risk factors in patients with NAFLD,and puts forward the prevention and cure measures of different constitution patients.Method:In this study,a total of 1273 patients with NAFLD were randomly selected from retired people in enterprises combination the results of physical examination and questionnaire,from March 2016 to September in a community of Hangzhou,and a total of 2073 patients with non-fatty liver were selected as the control group.The identification of physical medicine on two subjects,patients with physical analysis on the proportion of NAFLD distribution,the key observation of risk factors of fatty liver and the constitution of the patient to blood pressure,blood glucose and blood lipid,body mass index.Result:In the physical examination population,the proportion of NAFLD in phlegm dampness and dampness and heat was higher than that in the control group,with statistical difference.Investigation of 1273 cases of NAFLD patients with physical distribution of phlegm dampness constitution is the most(28.59%),followed by the normal constitution(25.29%),yin deficiency(14.77%)and Yang deficiency(9.27%),damp heat(7.54%),Qi Stagnation(5.1%),Qi deficiency(4.32%),special constitution(3.3%)and blood stasis(1.8%).The control group with normal quality the highest proportion(31.87%),followed by Yin deficiency(19.21%)and Yang deficiency(18.82%),phlegm dampness(9.19%),damp heat(4.99%),Qi deficiency(4.59%)and Qi Stagnation(4.25%),special constitution(4.25%),blood stasis(2.83%).The body mass index(BMI),blood pressure,blood sugar,blood lipid(TG,HDL-C,LDL-C),uric acid,ALT,AST,cholecystectomy and other factors were significantly higher in the NAFLD group than in the control group.All the above risk factors,including creatinine and TC abnormalities,the proportion of phlegm and dampness in the patients were all higher in the NAFLD group than in the control group,except for the TC factor,the other factors were the highest proportion of phlegm dampness in the NAFLD group;In NAFLD group the proportion of phlegm dampness and dampness heat blood glucose abnormalities were significantly higher than the control group,P<0.05,the difference was statistically significant;NAFLD group the proportion of phlegm dampness and dampness heat TC abnormalities were significantly higher than the control group,P<0.05,the difference was statistically significant;NAFLD group the proportion of phlegm dampness and dampness heat,qi stagnation,abnormal LDL-C was significantly higher than the control group,P<0.01,the difference was statistically significant.Conclusion:1.Phlegm dampness and dampness heat are closely related to NAFLD.To some extent,phlegm dampness and dampness heat are more susceptible to NAFLD,and the correction of this biased constitution should be included in the prevention and treatment of NAFLD.2.The risk factors of NAFLD include body mass index(BMI),blood pressure,blood sugar,blood lipid(TG,HDL-C,LDL-C),uric acid,ALT,AST,and cholecystectomy.Risk factors and types of physical fitness:(1)the risk factors of NAFLD are closely related to phlegm dampness,and the relative indexes of NAFLD patients who reflect phlegm dampness are more likely to exceed standard;(2)analysis of blood sugar factors:NAFLD with phlegm dampness,dampness heat are more likely to cause abnormal blood sugar,(3)total cholesterol(TC)factor analysis:NAFLD patients with phlegm dampness and dampness heat are more likely to cause TC anomaly;(4)low density lipoprotein(LDL-C)factor analysis:phlegm dampness and dampness heat,qi stagnation in NAFLD patients is more likely to cause abnormal LDL-C;In summary,there is a certain correlation between the risk factors of NAFLD and the type of Constitution:phlegm in patients with NAFLD is more likely to cause abnormal body mass index,blood pressure,blood glucose,blood lipid,liver function,serum creatinine,uric acid;phlegm dampness and dampness heat of NAFLD patients is more likely to cause abnormal blood glucose,TC;phlegm,damp heat,qi stagnation in NAFLD patients is more likely to cause abnormal LDL-C.