| Objective: To investigate the clinical value of serum Cys C concentration in the early diagnosis and treatment of intracranial aneurysms.Methods: Included393 patients with aneurysmal subarachnoid hemorrhage(rupture group)and 213 patients with aneurysmal non-subarachnoid hemorrhage(unruptured group)who were hospitalized in the Department of Neurosurgery of the First Affiliated Hospital of Xinjiang Medical University.Meantime,127 patients with benign positional vertigo who were hospitalized in the First Affiliated Hospital of Xinjiang Medical University were selected as the control group,and the serum Cys C levels and related clinical data of the selected subjects were statistically analyzed.Results: The difference test showed that there was no significant difference in serum Cys C levels between the control group(0.76±0.27)mg/L and the unruptured group(0.79±0.26)mg/L(t=1.114,p=0.266),There was a statistically significant difference in serum Cys C levels between the unruptured group(0.79±0.26)mg/L and the ruptured group(0.68±0.31)mg/L(t=4.753,P<0.05);Relevance analysis showed that the serum Cys C level was not related to the presence of intracranial aneurysm(P=0.736,OR=1.169,95%CI=0.472～2.892),but the serum Cys C level was an independent influencing factor for whether the intracranial aneurysm is ruptured(P=0.012,OR=0.401,95%CI=0.197～0.818).Conclusion: Regardless of difference test or regression analysis,the serum Cys C level between control group and patients with unruptured intracranial aneurysm is not statistically significant,indicating that the determination of serum Cys C concentration in patients with unruptured intracranial aneurysm has no clinical application value. |
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