A Study On The Correlation Between Emotional State And Immune Function Of Recipient After Heart Transplantation

Background:All strategies of clinical and basic research in organ transplantation stem from the understanding of the immune system.The rational use of immunosuppressants and individualized treatment are still the unsolved and exploring problems of immunologists.There is a certain correlation between emotion and the immune system of the population,and how the correlation between emotion and immune function of patients after heart transplantation needs to be explored.Objective:(1)To describe the current situation of the emotional state of the recipient after heart transplantation;(2)To explore the relationship between the emotional state and the immune function of the patient.Methods:From November 2018 to November 2019,44 patients were selected after heart transplantation in the heart transplant ward of a cardiovascular specialist hospital in Beijing.The data were collected using the general situation questionnaire,the profile of mood states short form,POMS-SF,and the drug use of immunosuppressants in patients,as well as the results of the T lymphocyte subsets of the subjects studied in the test system.Results:The overall emotional state of the patients improved day by day during postoperative hospitalization,and three emotional state surveys found that the total emotional score(TMD)M(Q1,Q3)representing the overall emotional state of the patients was 4.5(1.5,11.75),0(-2,6),-2(-4,5.5)showing a decreasing trend,respectively;Spearman correlation analysis showed that the total score of emotion score showed negative correlation with T lymphocyte index,and the highest negative correlation with CD4+cell percentage was-0.384(p<0.01).Kruskal-wallis rank sum test found that the total score of emotion score of NK cell percentage was different(p<0.05);The CD 19+of b lymphocytes measured in different emotional states of the same individual was statistically different,F=3.052,p<0.05.Spearman correlation analysis showed a positive correlation between the total score of emotion score and leukocyte count(r=0.216,p<0.05).The dose of Prednisone(B=-0.43,p<0.05),TMD(B=-0.238,p<0.05)and the dose of MMF(B=-0.224,p<0.05)were found to have negative effects on CD4+lymphocytes in multiple linear regression models.Pathway analysis showed that emotion mediated between Prednisone dose and CD4+lymphocyte percentage;regulated between MMF dose and CD 19+B lymphocyte percentage.