The Clinical Study Of Modified Qidongfugan Mixture Combined With Entecavir In Treating Hepatic Fibrosis Of Chronic Hepatitis B

Objective: Based on an in-depth understanding of the development process and diagnosis of chronic hepatitis B liver fibrosis,Jiawei Qidong Fugan Mixture combined with entecavir for clinical treatment of chronic hepatitis B liver fibrosis,and observe and record the symptoms of patients,Signs,biochemistry,liver stiffness and elasticity detection,serum fibrosis indicators,liver tissue biopsy and liver fibrosis stage changes,based on the results,discuss the clinical efficacy and mechanism of Jiawei Qidong Fugan Mixture,which is an anti-liver fiber Treatment requires more precise methods and ideas.Methods: Sixty patients with chronic hepatitis B liver fibrosis who were diagnosed in Jinan Infectious Disease Hospital(Chinese medicine syndrome is Qi and Yin deficiency,stasis and heat syndrome),and the 60 patients were equally divided according to random number table method There are 30 patients in each group of the experimental group and the control group.In addition to adjuvant therapy,the experimental group was given Jiawei Qidong Fugan Mixture combined with entecavir.In addition to the same adjuvant therapy,the control group was given Chinese patent medicine Anluo Huaxian Pill combined with entecavir.The total course of treatment was 26 weeks.Before and after changes in imaging,serology and clinical symptoms and signs.Clarify and analyze the specific clinical efficacy and related mechanism of Jiawei Qidong Fugan Mixture against liver fibrosis.Results: The two groups were treated for 26 weeks,and none of them was discontinued during the observation period.1.Comprehensive curative effect: The total curative effect of Jiawei Qidong Fugan Mixture against liver fibrosis was 63.33%,the effective rate was 13.33%,and the total effective rate 76.67%,and there is a significant difference compared with the control group(P <0.05);2.TCM syndromes: In terms of the total curative effect of TCM syndromes,the marked efficiency of Jiawei Qidong Fugan Mixture is 73.33%,the effective rate is 23.33%,the total effective rate is 96.70%,and its significant efficiency is significantly higher than that of the control group,which is significantly different from the control group(P <0.05).In addition,Jiawei Qidong Fugan Mixture is also effective in improving serum fiber markers,liver function and imaging,and it is significantly different from the control group(P <0.05).3.Safety evaluation:After comparing the safety data of the two groups before and after treatment,it was found that there was no obvious abnormal change in various indicators,indicating that Jiawei Qidong Fugan Mixture has good safety.Conclusion: Jiawei Qidong Fugan Mixture can effectively improve the TCM syndromes of patients with liver fibrosis,and has a significant effect on serum biochemistry and imaging.From the side,the treatment of Jiawei Qidong Fugan Mixture against liver fibrosis The ideas and methods are correct.Therefore,taking qi and yin deficiency and stasis and heat internal node as the main pathogenesis of liver fibrosis,the idea of treating liver fibrosis with the methods of supplementing qi and nourishing yin,removing stasis and clearing heat will develop the anti-liver fibrosis of Chinese and Western medicine To a huge boost.