The Study Of Human Amniotic Epithelial Cells Improving Fertility In Intrauterine Adhesion

Intrauterine adhesion(IUA)is adhesion of uterine cavity or cervical canal resulting as damage to the basal layer of endometrium,usually accompanied with fibrosis of endometrium.This often leads to pelvic pain,menstrual disorder,recurrent abortion or infertility,which is also referred to as Asherman syndrome.Previous studies have demonstrated that human amniotic epithelial cells(hAECs)have the potential to alleviate chemotherapy-induced ovarian damage.To identify whether hAECs have protective effect on IUA,we applied mechanical injury of uterine cavity in a murine model,which were treated with hAECs.Our results showed that hAECs significantly amplified endometrium thickness,increased endometrial glands and decreased fibrosis area.hAECs also improved pregnancy outcome in mice.Further study revealed that hAECs induced autophagy in injured endometrium through a paracrine way.In conclusion,hAECs have the potential to improve the fertility in IUA.