Study On The Relationship Between Pregnancy Hyperthyroidism And Perinatal Maternal And Fetal Outcomes

Objective We estimated the relationship between pregnancy with hyperthyroidism and perinatal maternal and child outcomes.Method1.Hyperthyroidism group: we choose the pregnant women with medical treatment and stable pregnancy complicated with hyperthyroidism;,who were regular delivery check-ups in our hospital from December 2013 to September 2019,and borned ≥20weeks,;control group: randomly selected total of 2301 pregnant women with normal thyroid function delivered in our hospital from January to November ≥20 weeks,there were 517 cases and 2301 controls.Analyzed the general data,pregnancy complications,complications,pregnant women’s delivery outcomes and perinatal outcomes.Results1.General information: The incidence of pregnant women with hyperthyroidism is0.82%.The gestational age of pregnant women with hyperthyroidism was smaller than that of the control group,P <0.05,which was statistically significant.There was no significant difference in age,pregnancy and parity between pregnant women with hyperthyroidism and pregnant women in the control group.2.Comparison of pregnancy comorbidities: The common pregnancy comorbidities of the two groups of pregnant women are HBV carriers,scar uterus,genital tract malformation,in vitro fertilization embryo transplantation,uterine fibroids,thrombocytopenia,anemia,pregnancy complicated with heart disease,The incidence of pregnant women with hyperthyroidism combined with IVF embryo transplantation,uterine fibroids,and anemia was higher than that of the control group,and the incidence of hepatitis B virus carriers was lower than that of the control group,P <0.05,which was statistically significant.3.Comparison of pregnancy complications: The incidence of pregnancy-associated diabetes in hyperthyroidism group is 23.21%,and the incidence of hypertension in pregnancy is 6.58%,both higher than the control group,and the incidence of intrahepatic cholestasis syndrome is lower than the control group,P < 0.05,with statistical significance.In the 35-year-old group,the incidence of pregnancy-associated diabetes mellitus,pregnancy-induced hypertension,and umbilical cord around the neck in the hyperthyroidism group was higher than that in the control group,P <0.05,which was statistically significant.In the ≥35 years old group,although there was no significant difference in pregnancy complications between the two groups,the incidence of pregnancy-associated diabetes in the hyperthyroidism group was 34.95%,which was higher than that in the control group.4.Comparing the delivery outcomes of the two groups of pregnant women,there was no significant difference in the rate of cesarean section between the hyperthyroidism group and the control group;the total labor of pregnant women with ≥28 weeks of vaginal delivery in the hyperthyroidism group was shorter than the control group,P <0.05,which was statistically significant.The postpartum hemorrhage rate and the amount of bleeding at 2 hours postpartum in the hyperthyroidism group were higher than those in the control group,P <0.05,which was statistically significant.The postpartum hemorrhage rate and the amount of bleeding at 2 hours postpartum in the hyperthyroidism group were higher than those in the control group,but P> 0.05,there was no significant difference between the two groups.5.Compared with the outcome of perinatal infants,the premature birth rate of pregnant women in hyperthyroidism group was 12.77%,and the incidence of stillbirth was 2.13%,which was higher than that of the control group,P <0.05,which was statistically significant;P <0.05,with statistical significance;<35 years old group,the premature birth rate and the incidence of stillbirth in pregnant women with hyperthyroidism were greater than the control group,and the incidence of giant children was less than the control group,P <0.05,with statistical significance;≥35 years old group,The incidence of stillbirth in the hyperthyroidism group was greater than that in the control group,P <0.05,which was statistically significant.6.Using multiple linear regression and logistic regression analysis,it was concluded that pregnancy combined with hyperthyroidism reduced the weight of full-term infants,shortened the total labor of vaginal delivery ≥28 weeks,and increased the amount of vaginal bleeding 2 hours after vaginal delivery.Hyperthyroidism positively affects the incidence of premature delivery,pregnancy with diabetes,hypertension during pregnancy,and anemia.conclusionPregnancy combined with hyperthyroidism increases adverse perinatal outcomes,attention should be paid to pre-pregnancy and pregnancy care,early diagnosis,active treatment of hyperthyroidism,multi-disciplinary cooperation,joint management,reduce and control the occurrence and development of complications of pregnancy complications,and reduce maternal and child dysfunction The ending happens.