Prevalence Of Brugada-type ECG Pattern And Arrhythmic Events Of Adults In Xiamen

Background:Brugada syndrome(BrS)is a disease with genetic predisposition that easily leads to malignant ventricular arrhythmic events.It is characterized by abnormal ECG,which can lead to sudden cardiac death.Three types of ECG finding have been described in Brugada syndrome.BrS is estimated to account for 4-12%of all SCD and at least 20%of all SCD without organic heart disease.The world-wide pooled prevalence of BrS was 0.5 per 1000.Brugada syndrome is concerned because of its high incidence in Southeast Asia and its high risk of sudden cardiac death in young adults.Fujian province is close to the coast of Southeast Asia and located in the high incidence area of Brugada syndrome,which provides unique advantageous condition for the study of Brugada syndrome.The study of Brugada syndrome will provide important information for the prevention and treatment of Brugada syndrome in Fujian province,the whole county and even the entire Southeast Asia.Objective:The main purpose of this study is to analyze the prevalence of Brugada-type ECG in Xiamen,and follow-up on the occurrence of arrhythmic events(arrhythmic events include sudden cardiac death,ventricular tachycardia,ventricular fibrillation and syncope).Methods and results:From 2009 to 2019,1.33 million patients with ECGs recorded during clinic visit or hospital admission from cardiac function department of the first affiliated hospital of Xiamen university.A total of 238 subjects were enrolled(217 adult maies(91.2%)and 21 adult females(8.8%).The prevalence of Brugada-type ECG is 1.8/10,000.102(42.9%)subjects carried type 1 Brugada-type ECG pattern,130(54.6%)subjects carried type 2 Brugada-type ECG and 6(2.5%)subjects carried type 3 Brugada-type ECG.The number of males subjects with type 1 BrEP were 88,type 2 BrEP were 123 and type 3 BrEP were 6,respectively.Meanwhile,the number of females with type 1 BrEP were 14,type 2 BrEP were 7 and type 3 BrEP were 0,respectively.The mean age carried type 1,2 and 3 BrEP was 53.3±1 5.2years old,52.6±15.5years old and 59.3±14.3years old.Among the subjects with Brugada-type ECG pattern,5 cases of syncope were reportedConclusion:The prevalence of Brugada-type ECG pattern of adults in Xiamen is higher,compared with previous reports,in this study we found that the prevalence of type 2 Brugada-type ECG pattern is higher than type 1 Brugada-type ECG pattern while type 3 Brugada-type ECG pattern has the lowest prevalence.Though with high prevalence but was not associated with increased mortality.