| Objective:Two hundred patients with Hashimoto’ s thyroiditis(HT)and 149 healthy people as control group were analyzed statistically.The rela tionship between 25(OH)D and HT and its TCM syndromes was studied,prov iding guidance for diagnosis and treatment.Methods:Collect the data of patients,strictly fol l ow the inclusion c riteria and exclusion criteria,25(OH)D were divided into three groups according to the standard,including sufficient,insufficient and defici ent.The thyroid function of Hashimoto thyroiditis(HT)was divided into three groups,normal thyroid function group,subclinical hypothyroidism gr oup,hypothyroidism group.TCM syndromes of patients with Hashimoto’s thyro iditis(HT)are divided into liver Qi stagnation group,phlegm andblood s tasis group,spleen and kidney yang deficiency group.The relationship bet ween 25(OH)D and Hashimoto thyroiditis(HT)and its TCM syndromes was s tudied.SPSS21.0 software was used to deal with the results.Results:1.The median of 25(OH)D in HT group was lower than that in control group,the difference is statistically significant.There was no significan t difference between 25(OH)D and age,sex in HT group.2.By spearman correlation analysis,25(OH)D in HT group was negativ ely correlated with TgAb.3.The distribution of three TCM syndrome types in HT group was the mo st in liver qi stagnation group and the least in spleen-kidney yang defic iency group.The mean age of spleen-kidney yang deficiency group was the largest and the proportion of 25(OH)D deficiency was the highest.4.Comparison of the number of patients with different stages of thyro id function in HT group:normal thyroid function>subclinical hypothyroid ism>hypothyroidism.There was no significant correlation between thyroid function and 25(OH)D at different stages5.In binary Logistic regression analysis,age,sex,body mass index(BMI),blood glucose,(GLU),insulin(INS)and other confounding factors were adjusted for HT as independent variables,25(OH)D was the protectiv e factor of Hashimoto’ s thyroiditis.Conclusion:1.Serum 25(OH)D level is negatively correlated with TgAb in middle aged women with Hashimoto’s thyroiditis.In the course of clinical diagno sis and treatment,we should pay attention to the increase of TgAb and fi nd and supplement 25(OH)D in time.2.The 25(OH)D deficiency rate of Hashimoto’s thyroiditis with splee n and kidney yang deficiency syndrome was higher than that of liver qi st agnation syndrome and phlegm and blood stasis syndrome type.3.The level of 25(OH)D in patients with Hashimoto’ s thyroiditis is generally lower than that in healthy people,and 25(OH)D is the protect ive factor of Hashimoto’ s thyroiditis.The significance of 25(OH)D shou Id be paid attention to clinically.Predictive 25(OH)D plays an import a nt role in thyroid autoimmune response. |
