| Objective:Through the clinical randomized controlled trial to observe the clinical efficacy of rosemary essential oil in the treatment of breast hyperplasia related breast pain,breast masses and so on,and carried out transdermal absorption experiments to study the transdermal absorption of rosemary essential oil.Methods:(1)Clinical trials:120 patients with breast hyperplasia will be randomly divided into treatment group and control group on a 3:1 scale,with rose mint diastolic essential oil and placebo treatment,respectively,and1 external smear per day.28 days of continuous use is 1 course of treatment.To observe the changes of clinical symptoms and signs of patients.(2)In vitro transdermal experiment:The transdermal local administration of rose peppermint essential oil was used to determine the transdermal rate of the main components of rose peppermint essential oil using the Menthol brain as a permeability stimulant.Verify the transdermal absorption effect of rose mint milk essential oil.Results:(1)The results of the VAS score showed that after the treatment of the two groups of patients,the treatment group P=0.00<0.05,indicating that the rose peppermint essential oil was effective in the treatment of pain;Control group P=0.103>0.05,placebo treatment of pain was ineffective.(2)The results of mass size score showed that after the treatment of the two groups of patients,the treatment group P=0.007<0.05,indicating that rose Menthol essential oil reduced breast mass effective;Control group P=0.326>0.05,placebo reduced breast masses ineffective.(3)The results of mass texture score showed that after the treatment of the two groups of patients,the treatment group P=0.000<0.05,indicating that the rose Menthol essential oil improved the texture of the mass,the control group P=0.326>0.05,and the placebo improved the texture of the mass was invalid.(4)The results of Chinese medicine syndrome score showed that after the treatment of the two groups of patients,the treatment group P=0.000<0.05,indicating that rose mint milk essential oil is effective in improving the symptoms of Chinese medicine;Control group P=0.083>0.05,placebo to improve Chinese medicine syndrome invalid.(5)The clinical results showed that the clinical efficiency of the treatment group was 100%,the control group was 10%,and the use of X~2test,X~2=43.83,P=0.000<0.05,the two groups had significant differences in efficiency.The efficacy of treatment group was significantly higher than that of control group.(6)The curative effect of TCM syndrome was X~2test,X~2=105.043,P=0.000<0.05.The two groups had significant differences in efficiency,and the curative effect was significantly higher in the treatment group than in the control group.(7)The total efficiency results showed that the total efficiency of the experimental group and the control group were 98.9%and 3.3%,respectively,with significant differences.Using the X~2test,X~2=129.00,P=0.000<0.05,the difference in efficiency between the two groups was significant.The efficacy of treatment group was significantly higher than that of control group.(8)During the treatment period,one patient in the treatment group and one in the control group developed drug rash.After the allergy patients stopped taking medicine in the two groups,the drug rash subsided on its own.Except for the drug rash,there were no other adverse reactions in the two groups.(9)The transdermal absorption experiment proved that with the extension of time,the cumulative release of the drug,the effectiveness time of the essential oil is about 5-6 H.After experiment 6h,the transdermal rate of Menthol in the drug exceeded 39.86%,It is indicated that the effective ingredients in rose peppermint essential oil are easy to penetrate the skin and can play a good therapeutic role.Conclusion:The results of clinical trials show that rose mint milk essential oil has a significant effect on relieving breast pain,reducing breast masses,and improving related TCM symptoms.The active ingredient in rose mint milk essential oil is easy to pass through the skin,so that the essential oil can better play a therapeutic role,and the essential oil has better transdermal properties,is effective,easy to use,and can be used clinically to relieve breast hyperplasia.Clinical symptoms. |
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