Curative Effect Observation Of Peitu Gudi Decoction In Treatment Of Idiopathic Membranous Nephropathy Due To Deficiency Of The Spleen And Kidney

Objective: To observe the efficacy and safety of Pedi Gudi Decoction on the treatment of Idiopathic membranous nephropathy(IMN)on the basis of CNI drugs,and provide new ideas for the treatment of IMN.Method: IMN patients who met the inclusion criteria were randomly divided into the experimental group and the control group according to the random number table method.Both groups were given CNI drugs(tacrolimus or cyclosporine A)and symptomatic treatment.The control group was treated with nephritis rehabilitation tablets(5 times a day,3 times a day,orally)on the basic treatment;For the basic treatment,add the soil and solid foundation soup.After 6 months of treatment,observe and record the 24-hour urine protein quantitation(24h-UTP),plasma albumin(ALB),anti-phospholipase A2 receptor antibody(PLA2R),triglyceride(TG)before and after treatment.),cholesterol(TCHO),low-density lipoprotein(LDL-C),serum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(GFR)and other indicators as well as TCM syndrome scores and clinical efficacy,while The concentration of tacrolimus/cyclosporine blood trough was measured.Result: A total of 59 patients in this trial completed 6 months of observation,including 30 in the experimental group and 29 in the control group.There were no significant differences in laboratory indicators and TCM syndrome scores between the two groups before treatment,which were comparable(P>0.05).(1)24-hour urine protein quantification: 24 h-UTP was decreased in both groups after treatment,and the difference was statistically significant(P<0.01).After treatment,the test group was low in 24 h-UTP.In the control group(P <0.01).(2)Serum albumin: The ALB levels in both groups were increased after treatment,and the difference was statistically significant(P<0.01).After treatment,the ALB in the test group was higher than that in the control group.P < 0.01).(3)Blood lipids: After treatment,the TG,TCHO and LDL-C of the two groups were decreased,the difference was statistically significant(P<0.01).After treatment,the TG,TCHO and LDL-C were lower than the test group.Control group(P<0.05).(4)Serum anti-phospholipase A2 receptor antibody: PLA2 R decreased after treatment,the difference was statistically significant(P<0.01);after treatment,the PLA2 R of the experimental group was lower than the control group(P<0.05).).(5)Renal function: After treatment,the level of Scr in the experimental group was lower than that before treatment,and the difference was statistically significant(P<0.05).There was no statistical difference between the control group and Scr after treatment(P>0.05).There was no statistical difference between the Scr groups after treatment(P>0.05).The difference of urea nitrogen and glomerular filtration rate after treatment was not statistically significant(P>0.05).(6)TCM syndrome scores: After treatment,the symptoms of both groups were significantly improved.Compared with before treatment,the difference was statistically significant(P<0.01).After treatment,the TCM syndrome scores were compared between the experimental group and the control group.<0.01).(7)Efficacy of IMN: After treatment,the total effective rate of the experimental group was 86.7%,and the total effective rate of the control group was 75.9%.The total effective rate was higher in the comparison group than in the control group(P<0.05).(8)TCM syndrome efficacy: After treatment,the total effective rate of the experimental group was 90%,and the total effective rate of the control group was 65.5%.The comparison between the TCM symptom group and the control group was higher than that of the control group(P<0.05).Conclusion: Peigu Gudi Decoction combined with CNI drugs for the treatment of IMN can not only effectively improve the symptoms and signs of patients,but also reduce the proteinuria level of patients,increase plasma albumin,delay the progression of renal function,and regulate dyslipidemia.