| ObjectiveIn this study,clinical randomized controlled trials were conducted to observe the improvement of TCM symptoms,phlegm-dampness constitution and blood pressure of patients with hypertension and phlegm-dampness constitution by Shi eliminating tea,so as to offer TCM clinical research evidence for the treatment of hypertension.MethodAccording to the diagnostic criteria of the "Guidelines for Prevention and Treatment of Hypertension in China"(2010 Revision)and the Chinese Medicine Constitution Rating Scale(issued by the Chinese Academy of Traditional Chinese Medicine in 2009),a total of 60 patients with hypertension and phlegm-dampness constitution treated in the internal medicine clinic of Guangdong Provincial Hospital of Traditional Chinese Medicine and volunteers recruited by society were selected and randomly divided into tea drinking group and control group with 30 cases in each group.The tea drinking group took amlodipine besv late tablets orally with drinking Shi eliminating tea,while the control group took amlodipine besylate tablets alone.One pack of Shi eliminating tea daily(mix cangshu 5 g,suye 3 g,jiegeng 3g,chenpi 5 g,yiyiren 3g,gancao 3g and fuling 5g together,pack with tea filter paper,add 600ml of water to boil for 10 minutes,drink 300ml from 8:00 to 10:00 in the morning,and warm the remaining 300ml at 15:00 to 17:00 in the afternoon),amlodipine besylate tablet 5mg qd,and taking continuously for 12 weeks.If the blood pressure does not reach standard during the treatment,oral antihypertensive drugs such as angiotensin converting enzyme inhibitor and diuretic can be added according to the condition.The patient’s condition was evaluated before and 12 weeks after the intervention.According to the "hypertension symptom grading quantitative standard" to compare the symptom changes,the " Chinese medicine constitution scale”to evaluate the constitution state and then recording the blood pressure level.At the same time,the safety indexes of patients before and after treatment were checked.Results1.There was no significant difference in course of disease,sex,age,TCM syndrome score,phlegm-dampness constitution score and blood pressure level between the tea drinking group and the control group before treatment(P>0.05).2.In terms of TCM syndromes,the scores of TCM syndromes before and after treatment in the tea drinking group and the control group were compared in the group.The scores after treatment in the tea drinking group and the control group were lower than those before treatment,and the difference was statistically significant(p<0.001).The D-value of TCM syndrome scores before and after treatment was compared between the two groups.The D-value in tea drinking group(=4.67)was greater than that in another group(=2.97),and there was a meaningful difference statistically(P<0.05).3.Phlegm-dampness constitution score of tea drinking group and control group after treatment was lower than that of before,the difference was statistically useful(P<0.05);The D-value of phlegm-dampness constitution score before and after treatment was greater in tea drinking group(=11.07)than that in control group(=1.13),the D-value was statistically significant(P<0.001).4.The systolic and diastolic blood pressures of tea drinking group and control group after treatment were lower than those before treatment,with statistical significance(P<0.001);The D-value of systolic blood pressure before and after treatment in tea drinking group(=21.70)was higher than that in control group(=10.80),with statistical significance(P<0.001);The difference of diastolic blood pressure between the two groups before and after treatment showed no statistical difference(P>0.05).5.About clinical curative effect,the curative effect of TCM syndrome integral between the tea drinking group and the control group has statistical difference(P<0.05),and the curative effect of tea drinking group(total effective rate 73.3%)is better than that of control group(total effective rate 33.3%);The antihypertensive effect between the tea drinking group and the control group has statistical difference(P<0.05),and the antihypertensive effect of tea drinking group(total effective rate 70.0%)is better than that of control group(total effective rate 40.0%).6.No adverse events occurred in the treatment process of the tea drinking group and the control group of patients.ConclusionCompared with the control group,the tea drinking group has better curative effect in reducing systolic blood pressure level of patients with hypertension and phlegm-dampness constitution,improving symptoms and phlegm-dampness constitution,which is safe and suitable for popularization and application. |
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