The Role Of Serum Stanniocalcin-1 In Chronic Obstructive Pulmonary Disease

Objective:To investigate the serum level of stanniocalcin-1(STC1)in patients with stable chronic obstructive pulmonary diseases(COPD)and to explore the relationship between STC1 and severity of the disease.Method:55 patients with definite stable COPD and 24 healthy controls were enrolled in this study.Serum STC1 was measured by Enzyme-linked immunosorbent assay(ELISA),and the correlation between STC1 and COPD was analyzed.Results:1)Serum STC1 levels were significantly lower in patients with COPD than healthy controls(p<0.05).2)The receiver-operating characteristic(ROC)curve of serum SCT1 was used for threshold identification(area=0.6591,p=0.0252),the optimal cut-off point of serum STC1 was 1350 pg/ml(sensitivity 81.82%,specificity 50%,respectively).3)Poor association of serum STC1 levels with stable COPD was found,including the GOLD classification,COPD assessment test(CAT)scores and lung functions.Conclusion:Serum STC1 levels were significantly decreased in COPD patients while it is poorly correlated with disease severity.STC1 might have clinical application in stable COPD.