Efficacy Of Pregabalin Combined With Celecoxib On Pain After Arthroscopic Repair Of Rotator Cuff Injury

Objective To observe the effect of pregabalin combined with celecoxib on pain relief after arthroscopic repair of rotator cuff injury.Methods: Patients undergoing arthroscopic repair for rotator cuff injury at the Department of Joint Surgery Minda Hospital to Hubei Minzu University from June 2020 to November 2021 were collected,and a total of 90 cases were selected and randomly divided into three groups according to the random number table method: celecoxib group,pregabalin group,and pregabalin combined with celecoxib group,with 30 cases in each group.Visual analogue pain score（VAS）,postoperative opioid dosage,pre-operative and 3-month postoperative joint function scores,and patient’s postoperative adverse effects（e.g.,nausea or vomiting,dizziness,urinary retention,drowsiness,etc.）were recorded before and at 6 hours,12 hours,24 hours,2 days,3 days,7 days,2 weeks,and 3 months after surgery for assessment.The results were analyzed by statistical software SPSS.Results: 1.There was no statistically significant difference between the three groups in terms of general condition,operative time,preoperative VAS score,and preoperative and postoperative Constant-Murley functional scores of the shoulder joint（P > 0.05）.2.The differences in VAS scores at rest at 6 h,12 h,24 h,2 days,and 3 days postoperatively were not statistically significant in the pregabalin group compared with the celecoxib group（P >0.05）;at rest at 7 days,2 weeks,and 3 months postoperatively,VAS scores were lower in the pregabalin group than in the celecoxib group,and the differences were statistically significant（P < 0.05）;at rest at all time points postoperatively,VAS scores were lower in the pregabalin combined with celecoxib group than in the celecoxib group（P < 0.05）.Celecoxib group was lower than the celecoxib group at rest at all postoperative time points（P < 0.05）,and the difference was statistically significant;the difference between the VAS scores at rest at 6 hours and 3 months postoperatively in the pregabalin group and the pregabalin combined with celecoxib group was not statistically significant（P > 0.05）,and the VAS scores at rest at other postoperative time points in the pregabalin combined with celecoxib group was lower than the pregabalin group,and the difference was statistically significant（P < 0.05）.3.There was no statistically significant difference between the opioid dosage in the celecoxib group and the pregabalin group（P > 0.05）,and the opioid dosage in the pregabalin combined with celecoxib group was less than that in the celecoxib and pregabalin groups（P < 0.05）,and the difference was statistically significant.4.Analysis of postoperative adverse reactions in the three groups: nausea and vomiting were less in the pregabalin combined with celecoxib group and pregabalin group than in the celecoxib group,and the difference was statistically significant（P < 0.05）;the difference was not statistically significant（P > 0.05）when comparing the pregabalin group with the pregabalin combined with celecoxib group;drowsiness,urinary retention,dizziness,and weakness were not statistically significant when comparing between the three groups The differences were not statistically significant（P > 0.05）.Conclusion: 1 The analgesic effect of pregabalin combined with celecoxib was significantly better than that of celecoxib and pregabalin alone.2.Pregabalin combined with celecoxib and pregabalin was better than celecoxib in the treatment of chronic pain.3.The pregabalin combined with celecoxib group can reduce the use of postoperative opioids compared with the pregabalin and celecoxib groups.4.Pregabalin combined with celecoxib reduces the incidence of postoperative nausea and vomiting compared with pregabalin and celecoxib.